Find our articles on PubMED

2024

  1. Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Böttcher JP, Brabletz S, Brabletz T, Brown AR, Brüne B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distéfano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, García-Sáez AJ, Garbowicz K, Götz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, Le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton AV, Min J, Mishima E, Müller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, Vanden Berghe T, Venkataramani V, Vogel FCE, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wölk M, Wu K, Yang X, Yu F, Zou Y, Conrad M. Ferroptosis in Health and Disease. Redox Biology. 2024:103211. doi: https://doi.org/10.1016/j.redox.2024.103211. [Link]
  2. Jiang Y, Khoury EE, Pezacki AT, Qian N, Oi M, Torrente L, Miller S, Ralle M, DeNicola G, Min W, Chang C. An Activity-Based Sensing Approach to Multiplex Mapping of Labile Copper Pools by Stimulated Raman Scattering. ChemRxiv. 2024; doi:10.26434/chemrxiv-2024-l0v7x [ChemRxiv]
  3. Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solís C, Hasnain Y, Novikova A, Endress JE, González-Sánchez P, Dong W, Stephanopoulos G, DeNicola GM, Harris I, Sept D, Mason FM, Coloff JL. Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy. JCI Insight. 2024 May 30:e174329. doi: 10.1172/jci.insight.174329. [Pubmed][Link][BioRxiv]
  4. Ward NP, Yoon SJ, Flynn T, Sherwood AM, Olley MA, Madej J, DeNicola GM. Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC. Nat Commun. 2024 May 18;15(1):4244. doi: 10.1038/s41467-024-48695-2.[Pubmed][Link][BioRxiv]
  5. Jasani N, Xu X, Posorske B, Kim Y, Vera O, Tsai KY, DeNicola GM, Karreth FA. MAPK-mediated PHGDH induction is essential for melanoma formation and represents an actionable vulnerability. bioRxiv [Preprint]. 2024 Apr 15:2024.04.11.589139. doi: 10.1101/2024.04.11.589139.[Pubmed][BioRxiv]

2023

  1. Greenwood HE, Edwards RS, Tyrrell WE, Barber AR, Baark F, Tanc M, Khalil E, Falzone A, Ward NP, DeBlasi JM, Torrente L, Pearce DR, Firth G, Smith LM, Timmermand OV, Huebner A, George ME, Swanton C, Hynds RE, DeNicola GM, Witney TH. Imaging the master regulator of the antioxidant response in non-small cell lung cancer with positron emission tomography. bioRxiv, 2023.2012.2016.572007. doi:10.1101/2023.12.16.572007. [BioRxiv]
  2. Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns P, Rawat V, Sheldon R, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL. ASCT2 is the primary serine transporter in cancer cells. bioRxiv [Preprint]. 2023 Oct 11:2023.10.09.561530. doi: 10.1101/2023.10.09.561530. [BioRxiv]
  3. Asantewaa G, Tuttle ET, Ward NP, Kang YP, Kim Y, Kavanagh ME, Girnius N, Chen Y, Duncan R, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller, L Scales TQ, Taylor K, Alimohammadi F, Sechrist ZR, Agoustini-Vulaj D, Schafer XL, Chang H, Smith Z, O'Connor TN, Whelan S, Selfors LM, Crowdis J, Gray GK, Bronson RT, Brenner D, Ruffini A, Dirksen RT, Hazel AF, Huber AR, Munger J, Cravatt BF, Vasiliou V, Cole CL, DeNicola GM, Harris IS. Glutathione supports lipid abundance in vivo. bioRxiv 2023.02.10.524960; doi: https://doi.org/10.1101/2023.02.10.524960 [BioRxiv]
  4. Sebastian NT, Webb A, Shilo K, Robb R, Xu-Welliver M, Haglund K, Brownstein J, DeNicola GM, Shen C, Williams TM. A PI3K gene expression signature predicts for recurrence in early-stage non–small cell lung cancer treated with stereotactic body radiation therapy (SBRT). Cancer. 2023; 1-7. doi:10.1002/cncr.34983 [Pubmed][Link]
  5. Kang YP, DeNicola GM. Quantification and Tracing of Stable Isotope into Cysteine and Glutathione. Methods Mol Biol. 2023;2675:51-63. doi: 10.1007/978-1-0716-3247-5_5. [Pubmed][Link]
  6. DeBlasi JM, Falzone A, Caldwell S, Kang YP, Prieto-Farigua N, Prigge JR, Schmidt EE, Chio IIC, Karreth FA, DeNicola GM. Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression. Cancer Res. 2023 Apr 16:CAN-22-3848. doi: 10.1158/0008-5472.CAN-22-3848. Epub ahead of print. [Pubmed][Link][BioRxiv]
  7. Torrente L, DeNicola GM. GAPDH redox redux-rewiring pentose phosphate flux. Nat Metab. 2023 Apr 6. doi: 10.1038/s42255-021-00523-3. [Pubmed][Link]
  8. Dutta T, Kapoor N, Mathew M, Chakraborty SS, Ward NP, Prieto-Farigua N, Falzone A, DeLany JP, Smith SR, Coen PM, DeNicola GM, Gardell SJ. Source of nicotinamide governs its metabolic fate in cultured cells, mice, and humans. Cell Rep. 2023 Mar 28;42(3):112218. doi: 10.1016/j.celrep.2023.112218. Epub 2023 Mar 9. [Pubmed][Link]
  9. Yoon SJ, Combs JA, Falzone A, Prieto-Farigua N, Caldwell S, Ackerman HD, Flores ER, DeNicola GM. Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors. 2023 May 2;83(9):1426-1442. doi: 10.1158/0008-5472.CAN-22-3000. [Pubmed][Link][BioRxiv]
  10. Ilter D, Drapela S, Schild T, Ward NP,  Adhikari E, Low V, Asara J, Oskarsson T, Le-Lau E, DeNicola GM, McReynolds MR, Gomes AP. NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Redox Biol. 2023, 102627. doi: https://doi.org/10.1016/j.redox.2023.102627. [Link][BioRxiv]

2022

  1. Van Oss SB, Parikh SB, Coelho NC, Wacholder A, Belashov I, Zdancewicz S, Michaca M, Xu J, Kang YP, Ward NP, Yoon SJ, McCourt KM, McKee J, Ideker T, VanDemark AP, DeNicola GM, Carvunis AR. On the illusion of auxotrophy: met15Δ yeast cells can grow on inorganic sulfur thanks to the previously uncharacterized homocysteine synthase Yll058w. J Biol Chem. 2022 Nov 12:102697. doi: 10.1016/j.jbc.2022.102697. [Pubmed][Link] [bioRxiv]
  2. Pezacki AT, Matier CD, Gu X, Kummelstedt E, Bond SE, Torrente L, Jordan-Sciutto KL, DeNicola GM, Su TA, Brady DC, Chang CJ. Oxidation state-specific fluorescent copper sensors reveal oncogene-driven redox changes that regulate labile copper(II) pools. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2202736119. doi: 10.1073/pnas.2202736119. [Pubmed][Link]
  3. Ward NP, DeNicola GM. Long-sought mediator of vitamin K recycling discovered. Nature. 2022 Aug 3. doi: 10.1038/d41586-022-02001-6. [Pubmed][Link]
  4. Ravichandran M, Hu J, Cai C, Ward NP, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey CJ, Yang Y, Desousa BR, Rademaker G, Staes AAL, Cakir Z, Jain IH, Aguirre AJ, Mancias JD, Shen Y, DeNicola GM, Perera RM. Coordinated transcriptional and catabolic programs support iron dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer. Cancer Discov 2022; cd.22.0044. https://doi.org/10.1158/2159-8290.CD-22-0044 [Pubmed][Link]
  5. Jiang C, Ward NP, Prieto-Farigua N, Kang YP, Thalakola A, Teng M, DeNicola GM. A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer. Redox Biol. 2022 54: 102358, doi: https://doi.org/10.1016/j.redox.2022.102358 [Pubmed][Link][BioRxiv]
  6. Wang X, Li Y, Li Z, Lin S, Wang H, Sun J, Lan C, Wu L, Sun D, Huang C, Singh PK, Hempel N, Trebak M, DeNicola GM, Hao J, Yang S. Mitochondrial calcium uniporter drives metastasis and confers a targetable cystine dependency in pancreatic cancer. Cancer Res. 2022 Jun 15;82(12):2254-2268. doi: 10.1158/0008-5472.CAN-21-3230. [Pubmed][Link]
  7. Mecozzi N, Nenci A, Vera O, Falzone A, DeNicola GM, Karreth FA. Genetic tools for the stable overexpression of circular RNAs. RNA Biol. 2022 Jan;19(1):353-363. doi: 10.1080/15476286.2022.2043041. [Pubmed][Link][BioRxiv]
  8. Li J, DeNicola GM, Ruffell B. Metabolism in tumor-associated macrophages. International Review of Cell and Molecular Biology. 2022;367:65-100. doi: 10.1016/bs.ircmb.2022.01.004.[Pubmed][Link]
  9. Ge EJ, Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou QP, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LT, Van Aelst L, Xi D, Yuan P, Brady DC, Chang CJ. Connecting copper and cancer: from transition metal signalling to metalloplasia. Nat Rev Cancer. 2022 Feb;22(2):102-113. doi: 10.1038/s41568-021-00417-2. [Pubmed][Link][PDF]
  10. Torrente L, DeNicola GM. Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges. Annu Rev Pharmacol Toxicol. 2022 Jan 6;62:279-300. doi: 10.1146/annurev-pharmtox-052220-104025. [Pubmed][Link][PDF]

2021

  1. Yoon SJ, DeNicola GM. IL1RAP Pulls a Double Shift in the Cysteine Factory. Cancer Discov. 2021 Nov;11(11):2679-2681. doi: 10.1158/2159-8290.CD-21-1053. [Pubmed][Link]
  2. Lin S, Yunzhan Li, Wang D, Huang C, Marino D, Bollt O, Wu C, Taylor M, Li W, DeNicola GM, Hao J, Singh PK, Yang S. Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression. Cancer Lett. 2021 Oct 10;518:230-242. doi: 10.1016/j.canlet.2021.07.025. [Pubmed][Link][bioRxiv]
  3. DeNicola GM, Shackelford DB. Metabolic Phenotypes, Dependencies, and Adaptation in Lung Cancer. Cold Spring Harb Perspect Med. 2021 Nov 1;11(11):a037838. doi: 10.1101/cshperspect.a037838. [Pubmed][Link]
  4. González-Sánchez P, DeNicola GM. The microbiome(s) and cancer: know thy neighbor(s). J Pathol. 2021 Jul;254(4):332-343. doi: 10.1002/path.5661. [Pubmed][Link][PDF]
  5. Ward NP, DeNicola GM. GSH hoards all the cysteine-what a slimy thing to do. Nat Metab. 2021 Mar;3(3):297-298. doi: 10.1038/s42255-021-00365-z. [Pubmed][Link][PDF]
  6. Beato F, Reverón D, Dezsi KB, Ortiz A, Johnson JO, Chen DT, Ali K, Yoder SJ, Jeong D, Malafa M, Hodul P, Jiang K, Centeno BA, Abdalah MA, Balasi JA, Tassielli AF, Sarcar B, Teer JK, DeNicola GM, Permuth JB, Fleming JB. Establishing a Living Biobank of Patient-Derived Organoids of Intraductal Papillary Mucinous Neoplasms of the Pancreas. Lab Invest. 2021 Feb;101(2):204-217. doi: 10.1038/s41374-020-00494-1. [Pubmed][Link][BioRxiv]
  7. Kang YP, Mockabee-Macias A, Jiang C, Falzone A, Prieto-Farigua N, Stone E, Harris IS, DeNicola GM. Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. Cell Metab. 2021 Jan 5;33(1):174-189.e7. doi: 10.1016/j.cmet.2020.12.007. [Pubmed][Link][PDF][BioRxiv]

2020

  1. DeBlasi JM and DeNicola GM. Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer. Cancers (Basel). 2020 Oct 17;12(10):3023. doi: 10.3390/cancers12103023.[Pubmed][Link
  2. Combs JA and DeNicola GM. The smell of death and deCYStiny: polyamines play the hero. Nat Metab. 2020 Oct;2(10):995-996. doi: 10.1038/s42255-020-0260-3. [Pubmed][Link][Free access]
  3. Kang, YP, Falzone, A, Liu, M, González-Sánchez P, Choi BH, Coloff JL, Saller JJ, Karreth FA, DeNicola GM. PHGDH supports liver ceramide synthesis and sustains lipid homeostasis. Cancer Metab. 2020 Jun 15;8:6. doi: 10.1186/s40170-020-00212-x. eCollection 2020. [Pubmed][Link][BioRxiv]
  4. Ward NP and DeNicola GM. The Golgi: Keeping It Unapologetically Basic. Cancer Discov. 2020 Jun;10(6):768-770. doi: 10.1158/2159-8290.CD-20-0357. [Pubmed][Link][PDF]
  5. Harris IS, DeNicola GM. The Complex Interplay between Antioxidants and ROS in Cancer. Trends Cell Biol. 2020 Jun;30(6):440-451. doi: 10.1016/j.tcb.2020.03.002. [Pubmed][Link][PDF]
  6. Ward NP, Kang YP, Falzone A, Boyle TA, DeNicola GM. NNT Regulates Mitochondrial Metabolism in NSCLC Through Maintenance of Fe-S Protein Function. J Exp Med. 2020 Jun 1;217(6). pii: e20191689. doi: 10.1084/jem.20191689. [Pubmed][Link][bioRxiv]
  7. Torrente L, Prieto N, Falzone A, Elkins CM, Boothman DA, Haura EB, DeNicola GM. Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone. Redox Biol. 2020 Feb;30:101440. doi: 10.1016/j.redox.2020.101440. [Pubmed][Link] [BioRxiv]
  8. Cheung EC, DeNicola GM, Nixon C, Blyth K, Labuschagne CF, Tuveson DA, Vousden KH. Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer. Cancer Cell. 2020 Feb 10;37(2):168-182.e4. doi: 10.1016/j.ccell.2019.12.012. [Pubmed] [Link]

2019

  1. Ward NP, DeNicola GM. Sulfur metabolism and its contribution to malignancy. Int Rev Cell Mol Biol. 2019;347:39-103. doi: 10.1016/bs.ircmb.2019.05.001. [Pubmed][Link]
  2. Stewart PA, Welsh EA, Slebos RJC, Fang B, Izumi V, Chambers M, Zhang G, Cen L, Pettersson F, Zhang Y, Chen Z, Cheng CH, Thapa R, Thompson Z, Fellows KM, Francis JM, Saller JJ, Mesa T, Zhang C, Yoder S, DeNicola GM, Beg AA, Boyle TA, Teer JK, Ann Chen Y, Koomen JM, Eschrich SA, Haura EB. Proteogenomic landscape of squamous cell lung cancer. Nat Commun. 2019 Aug 8;10(1):3578. doi: 10.1038/s41467-019-11452-x. [Pubmed][Link]
  3. Humpton TJ, Alagesan B, DeNicola GM, Lu D, Yordanov GN, Leonhardt CS, Yao MA, Alagesan P, Zaatari MN, Park Y, Skepper JN, Macleod KF, Perez-Mancera PA, Murphy MP, Evan GI, Vousden KH, Tuveson DA. Oncogenic Kras induces Nix-mediated mitophagy to promote pancreatic cancer. Cancer Discov. 2019 Sep;9(9):1268-1287. doi: 10.1158/2159-8290.CD-18-1409. [Pubmed][Link]
  4. Kang YP, Torrente L, Falzone A, Elkins CM, Liu M, Asara JM, Dibble CC, DeNicola GM. Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer. Elife. 2019 May 20;8:e45572. doi: 10.7554/eLife.45572. [Pubmed][Link][bioRxiv]
  5. Combs JA, DeNicola GM. The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival. Cancers (Basel). 2019 May 16;11(5):678. doi: 10.3390/cancers11050678. [Pubmed] [Link]
  6. Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi: 10.1016/j.cmet.2019.01.020. [Pubmed] [Link]

2018

  1. Kang YP, Ward NP, DeNicola GM. Recent advances in cancer metabolism: a technological perspective. Exp Mol Med. 2018 Apr 16;50(4):1-16. doi: 10.1038/s12276-018-0027-z. [Pubmed] [Link]
  2. Lee SB, Sellers B, DeNicola G. The regulation of NRF2 by nutrient responsive signaling and its role in anabolic cancer metabolism. Antioxid Redox Signal. 2018 Dec 10;29(17):1774-1791. doi: 10.1089/ars.2017.7356. [Pubmed] [Link] [PDF]

2017

  1. Torrente L, DeNicola GM. Stressing Out PanIN: NRF2 Pushes over the Edge. Cancer Cell. 2017 Dec 11;32(6):723-725. doi: 10.1016/j.ccell.2017.11.014. [Pubmed] [Link]
  2. Permuth JB, Choi JW, Chen DT, Jiang K, DeNicola G, Li JN, Coppola D, Centeno BA, Magliocco A, Balagurunathan Y, Merchant N, Trevino JG, Jeong D. A pilot study of radiologic measures of abdominal adiposity: weighty contributors to early pancreatic carcinogenesis worth evaluating? Cancer Biol Med. 2017 Feb;14(1):66-73. [Pubmed]

Selected publications pre-2017

  1. Chio II, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee E, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia J, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA. NRF2 mediates redox-dependent mRNA translation and tumor maintenance in pancreatic cancer. Cell. 2016 Aug 11;166(4):963-76. [Pubmed] [Link]
  2. Mullarky E, Lucki NN, Zavareh RB, Anglin J, Gomes AP, Nicolay BN, Wong JCY, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, Lyssiotis CA, Lairson LL, Cantley LC. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. PNAS. 2016 Feb 16;113(7):1778-83. [Pubmed] [Link]
  3. DeNicola GM and Cantley LC. Cancer’s fuel choice: new flavors for a picky eater. Mol Cell. 2015 Nov 19;60(4):514-23. [Pubmed] [Link]
  4. DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Tang H, Xie Y, Asara JM, Huffman KE, Witsuba II, Minna JD, DeBerardinis RJ, and Cantley LC. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nature Genetics. 2015. Dec;47(12):1475-81. doi: 10.1038/ng.3421. [Pubmed] [Link]
  5. Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, Krauthammer M, Halaban R, Provero P, Adams DJ, Tuveson DA, Pandolfi PP. In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell. 2011 Oct 14;147(2):382-95. [Pubmed] [Link]
  6. Karreth FA, Frese KK, DeNicola GM, Baccarini M, and Tuveson DA. C-Raf is required for the initiation of lung cancer by K-RasG12DCancer Discov. 2011 Jul;1(2):128-136. [Pubmed] [Link]
  7. DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, and Tuveson DA. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 2011 Jul 6;475(7354):106-9. [Pubmed] [Link]
  8. Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L, Warren A, Scott H, Madhu B, Sharma N, Bon H, Zecchini V, DeNicola GM, Mathews N, Osborne M, Hadfield J, MacArthur S, Adryan B, Grigorenko E, Lyons SK, Brindle KM, Griffiths J, Gleave ME, Rennie PS, Neal DE and Mills IG. The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J. 2011 May 20;30(13):2719-33. [Pubmed] [Link]
  9. Karreth FA, DeNicola GM, Winter SP, Tuveson DA. C-Raf inhibits MAPK activation and transformation by B-Raf(V600E). Mol Cell. 2009 Nov 13;36(3):477-86.  [Pubmed] [Link]
  10. Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science. 2009 Jun 12;324(5933):1457-61 [Pubmed] [Link]