Find our articles on PubMED


  1. Torrente L, DeNicola GM. Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges. Annu Rev Pharmacol Toxicol. 2021 Sep 9. doi: 10.1146/annurev-pharmtox-052220-104025. [Pubmed][Link]
  2. Lin S, Yunzhan Li, Wang D, Huang C, Marino D, Bollt O, Wu C, Taylor M, Li W, DeNicola GM, Hao J, Singh PK, Yang S. Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression. Cancer Lett. 2021 Jul 22;S0304-3835(21)00352-9. doi: 10.1016/j.canlet.2021.07.025.[Pubmed][Link][bioRxiv]
  3. Mecozzi N, Nenci A, Vera O, Falzone A, DeNicola GM, Karreth FA. Genetic tools for the stable overexpression of circular RNAs. bioRxiv 2021.05.27.446018; doi: [BioRxiv]
  4. DeNicola GM, Shackelford DB. Metabolic Phenotypes, Dependencies, and Adaptation in Lung Cancer. Cold Spring Harb Perspect Med. 2021 Jun 14:a037838. doi: 10.1101/cshperspect.a037838. Epub ahead of print. [Pubmed][Link]
  5. González-Sánchez P, DeNicola GM. The microbiome(s) and cancer: know thy neighbor(s). J Pathol. 2021 Mar 15. doi: 10.1002/path.5661. [Pubmed][Link][PDF]
  6. Ward NP, DeNicola GM. GSH hoards all the cysteine-what a slimy thing to do. Nat Metab. 2021 Mar;3(3):297-298. doi: 10.1038/s42255-021-00365-z. [Pubmed][Link][PDF]
  7. Beato F, Reverón D, Dezsi KB, Ortiz A, Johnson JO, Chen DT, Ali K, Yoder SJ, Jeong D, Malafa M, Hodul P, Jiang K, Centeno BA, Abdalah MA, Balasi JA, Tassielli AF, Sarcar B, Teer JK, DeNicola GM, Permuth JB, Fleming JB. Establishing a Living Biobank of Patient-Derived Organoids of Intraductal Papillary Mucinous Neoplasms of the Pancreas. Lab Invest. 2021 Feb;101(2):204-217. doi: 10.1038/s41374-020-00494-1. [Pubmed][Link][BioRxiv]
  8. Kang YP, Mockabee-Macias A, Jiang C, Falzone A, Prieto-Farigua N, Stone E, Harris IS, DeNicola GM. Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. Cell Metab. 2021 Jan 5;33(1):174-189.e7. doi: 10.1016/j.cmet.2020.12.007. [Pubmed][Link][PDF][BioRxiv]


  1. DeBlasi JM and DeNicola GM. Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer. Cancers (Basel). 2020 October 17;12(10), E3023. [Pubmed][Link
  2. Combs JA and DeNicola GM. The smell of death and deCYStiny: polyamines play the hero. Nat Metab. 2020 Aug 3. doi: 10.1038/s42255-020-0260-3. Online ahead of print. [Pubmed][Link][Free access]
  3. Kang, YP, Falzone, A, Liu, M, González-Sánchez P, Choi BH, Coloff JL, Saller JJ, Karreth FA, DeNicola GM. PHGDH supports liver ceramide synthesis and sustains lipid homeostasis. Cancer Metab 8, 6 (2020). doi: 10.1186/s40170-020-00212-x [Pubmed][Link][BioRxiv]
  4. Ward NP and DeNicola GM. The Golgi: Keeping It Unapologetically Basic. Cancer Discov. 2020 Jun;10(6):768-770. [Pubmed][Link][PDF]
  5. Harris IS, DeNicola GM. The Complex Interplay between Antioxidants and ROS in Cancer. Trends Cell Biol. 2020 Apr 14. pii: S0962-8924(20)30058-1. [Pubmed][Link][PDF]
  6. Ward NP, Kang YP, Falzone A, Boyle TA, DeNicola GM. NNT Regulates Mitochondrial Metabolism in NSCLC Through Maintenance of Fe-S Protein Function. J Exp Med. 2020 Jun 1;217(6). pii: e20191689. [Pubmed][Link][bioRxiv]
  7. Torrente L, Prieto N, Falzone A, Elkins CM, Boothman DA, Haura EB, DeNicola GM. Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone. Redox Biol. 2020 Feb;30:101440. [Pubmed][Link] [BioRxiv]
  8. Cheung EC, DeNicola GM, Nixon C, Blyth K, Labuschagne CF, Tuveson DA, Vousden KH. Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer. Cancer Cell. 2020 Jan 13. pii: S1535-6108(19)30582-3. doi: 10.1016/j.ccell.2019.12.012. [Pubmed] [Link]


  1. Ward NP, DeNicola GM. Sulfur metabolism and its contribution to malignancy. Int Rev Cell Mol Biol. 2019;347:39-103. Epub 2019 Jun 17. [Pubmed][Link]
  2. Stewart PA, Welsh EA, Slebos RJC, Fang B, Izumi V, Chambers M, Zhang G, Cen L, Pettersson F, Zhang Y, Chen Z, Cheng CH, Thapa R, Thompson Z, Fellows KM, Francis JM, Saller JJ, Mesa T, Zhang C, Yoder S, DeNicola GM, Beg AA, Boyle TA, Teer JK, Ann Chen Y, Koomen JM, Eschrich SA, Haura EB. Proteogenomic landscape of squamous cell lung cancer. Nat Commun. 2019 Aug 8;10(1):3578. [Pubmed][Link]
  3. Humpton TJ, Alagesan B, DeNicola GM, Lu D, Yordanov GN, Leonhardt CS, Yao MA, Alagesan P, Zaatari MN, Park Y, Skepper JN, Macleod KF, Perez-Mancera PA, Murphy MP, Evan GI, Vousden KH, Tuveson DA. Oncogenic Kras induces Nix-mediated mitophagy to promote pancreatic cancer. Cancer Discov. 2019 Jul 1. pii: CD-18-1409. [Pubmed][Link]
  4. Kang YP, Torrente L, Falzone A, Elkins CM, Liu M, Asara JM, Dibble CC, DeNicola GM. Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer. eLife 2019 May 20;8. pii: e45572. [Pubmed][Link][bioRxiv]
  5. Combs JA, DeNicola GM. The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival. Cancers (Basel). 2019 May 16;11(5). [Pubmed] [Link]
  6. Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metab. 2019 Feb 13. pii: S1550-4131(19)30020-8. [Pubmed] [Link]


  1. Kang YP, Ward NP, DeNicola GM. Recent advances in cancer metabolism: a technological perspective. Exp Mol Med. 2018 Apr 16;50(4):31. [Pubmed] [Link]
  2. Lee SB, Sellers B, DeNicola G. The regulation of NRF2 by nutrient responsive signaling and its role in anabolic cancer metabolism.Antioxid Redox Signal. 2018 Dec 10;29(17):1774-1791. [Pubmed] [Link] [PDF]


  1. Torrente L, DeNicola GM. Stressing Out PanIN: NRF2 Pushes over the Edge. Cancer Cell. 2017 Dec 11;32(6):723-725. [Pubmed] [Link]
  2. Permuth JB, Choi JW, Chen DT, Jiang K, DeNicola G, Li JN, Coppola D, Centeno BA, Magliocco A, Balagurunathan Y, Merchant N, Trevino JG, Jeong D. A pilot study of radiologic measures of abdominal adiposity: weighty contributors to early pancreatic carcinogenesis worth evaluating? Cancer Biol Med. 2017 Feb;14(1):66-73. [Pubmed]

Selected publications pre-2017

  1. Chio II, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee E, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia J, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA. NRF2 mediates redox-dependent mRNA translation and tumor maintenance in pancreatic cancer. Cell. 2016 Aug 11;166(4):963-76. [Pubmed] [Link]
  2. Moon JS, Stout-Delgado H, DeNicola GM, Koo MJ, Rooney KT, Yoon JH, Ryter SW, Nakahira K, Choi AM. NOX4-dependent fatty acid oxidation regulates NLRP3 inflammasome activation. Nature Medicine. 2016. Sep;22(9):1002-12. [Pubmed] [Link]
  3. Mullarky E, Lucki NN, Zavareh RB, Anglin J, Gomes AP, Nicolay BN, Wong JCY, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, Lyssiotis CA, Lairson LL, Cantley Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. PNAS. 2016 Feb 16;113(7):1778-83. [Pubmed] [Link]
  4. DeNicola GM and Cantley LC. Cancer’s fuel choice: new flavors for a picky eater. Review. Molecular Cell. 2015 Nov 19;60(4):514-23. [Pubmed] [Link]
  5. DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Tang H, Xie Y, Asara JM, Huffman KE, Witsuba II, Minna JD, DeBerardinis RJ, and Cantley LC. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nature Genetics. 2015. Dec;47(12):1475-81. doi: 10.1038/ng.3421. [Pubmed] [Link]
  6. Moon JS, Hisata S, Park MA, DeNicola GM, Ryter SW, Nakahira K, Choi AM. mTORC1 induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation. Cell Reports. 2015. Jul 7;12(1):102-15. [Pubmed] [Link]
  7. Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, Krauthammer M, Halaban R, Provero P, Adams DJ, Tuveson DA, Pandolfi PP. In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell. 2011 Oct 14;147(2):382-95. [Pubmed] [Link]
  8. Karreth FA, Frese KK, DeNicola GM, Baccarini M, and Tuveson DA. C-Raf is required for the initiation of lung cancer by K-RasG12DCancer Discov. 2011 Jul;1(2):128-136. [Pubmed] [Link]
  9. DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, and Tuveson DA. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 2011 Jul 6;475(7354):106-9. [Pubmed] [Link]
  10. Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L, Warren A, Scott H, Madhu B, Sharma N, Bon H, Zecchini V, DeNicola GM, Mathews N, Osborne M, Hadfield J, MacArthur S, Adryan B, Grigorenko E, Lyons SK, Brindle KM, Griffiths J, Gleave ME, Rennie PS, Neal DE and Mills IG. The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J. 2011 May 20;30(13):2719-33. [Pubmed] [Link]
  11. Karreth FA, DeNicola GM, Winter SP, Tuveson DA. C-Raf inhibits MAPK activation and transformation by B-Raf(V600E). Mol Cell. 2009 Nov 13;36(3):477-86.  [Pubmed] [Link]
  12. Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science. 2009 Jun 12;324(5933):1457-61 [Pubmed] [Link]