Our laboratory is engaged in both Bioinformatics and Clinical Informatics research projects. Recent informatics efforts in analyzing the tissue obtained from patients undergoing anti-PD-1 therapy demonstrated the importance of Inducible Nitric Oxide Synthase (iNOS). Informatics supplements our immunology work in that we have developed tools to allow for more efficient phenotyping of cells. Additionally, we collaborate with Biostatisticians such as Dr. Brooke Fridley to develop spatial informatics algorithms. Dr. Markowitz is actively engaged in clinical informatics, and these efforts have led to more efficient methods for determining response to therapy off clinical trials. We utilize informatics methods to inform our immunology, clinical, and biochemistry and biophysics research.
In the figure below we illustrate the pathway analysis for sorting out nitric oxide dependent effects in patients receiving anti-PD-1 therapy.