Sanne Olesen

Olesen Sanne

Research Scientist

Molecular Biology, Biochemistry, Protein Chemistry

Email: sanne.olesen@moffitt.org

Education

2006 Ph.D., Medicine. Faculty of Health Sciences, Aarhus University, Aarhus, Denmark. Dissertation project: “Identification and characterization of new potential oncogenes and tumour suppressor genes in human colorectal cancer” carried out at Molecular Diagnostic Laboratory, Dept. of Clinical Biochemistry, Aarhus University Hospital, Skejby Sygehus.

2002 M.Sc., Biology. Dept. of Biology, Aarhus University, Aarhus, Denmark. Dissertation project: “Investigation of possible causes of chromosomal instability in human bladder cancer” carried out at Molecular Diagnostic Laboratory, Dept. of Clinical Biochemistry, Aarhus University Hospital, Skejby Syge

Publications

  • Shigetomi K, Olesen SH, Yang Y, Mitsuhashi S, Schönbrunn E, and Ubukata M (2013) MurA as a primary target of Tulipalin B and 6-Tuliposide B. Biosci. Biotechnol. Biochem.. 77(12): 2517-19. PMID: 24317075
  • Martin MP, Olesen SH, Georg GI, and Schönbrunn E. (2013) The cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains. ACS Chemical Biology. 8(11): 2360-5. PMID: 24007471
  • Olesen SH*, Ingles DJ, Yang Y, Schönbrunn E. (2013) Differential antibacterial properties of the MurA inhibitors terreic acid and fosfomycin. Journal of Basic Microbiology, In Press, doi: 10.1002/jobm.201200617. PMID: 23686727 * denotes corresponding author
  • Zhu JY, Yang Y, Han H, Betzi S, Olesen SH, Marsilio F, Schönbrunn E. (2012) Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA). J Biol Chem. 2012 Apr 13;287(16):12657-67. PMID: 22378791
  • Han H, Yang Y, Olesen SH, Becker A, Betzi S, Schonbrunn E. The Fungal Product Terreic Acid is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA). Biochemistry. 2010 Apr 14. Pubmed ID: 20392080
  • Todd Funke, Yan Yang, Huijong Han, Martha Healy-Fried, Sanne Olesen, Andreas Becker, Ernst Schönbrunn (2009). Structural basis of glyphosate resistance resulting from the double mutation Thr97 -> Ile and Pro101 -> Ser in 5-enolpyruvylshikimate-3-phosphate synthase from Escherichia coli. The Journal of Biological Chemistry 284(15): 9854-60
  • Sanne Harder Olesen, Lise Lotte Christensen, Flemming Brandt Sørensen, Teresa Cabezon, Søren Laurberg, Torben Falck Ørntoft, and Karin Birkenkamp-Demtröder (2005). Human FK506 binding protein 65 is associated with colorectal cancer. Molecular and Cellular Proteomics 4(4):534-544
  • Karin Birkenkamp-Demtroder, Sanne Harder Olesen, Flemming B. Sørensen, Søren Laurberg, Päivi Laiho, Lauri A. Aaltonen and Torben F. Ørntoft (2005) Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. GUT 54(3): 374-384
  • Karin Birkenkamp-Demtroder, Lise Lotte Christensen, Sanne Harder Olesen, Casper M. Frederiksen, Päivi Laiho, Lauri A. Aaltonen, Søren Laurberg, Flemming B. Sørensen, Rikke Hagemann, and Torben F. Orntoft (2002) Gene expression in Colorectal Cancer. Cancer Research 62(15): 4352-63
  • Sanne Harder Olesen, Thomas Thykjaer, Torben Falck Ørntoft (2001). Mitotic checkpoint genes hBUB1, hBUB1B, hBUB3 and TTK in human bladder cancer, screening for mutations and loss of heterozygosity. Carcinogenesis 22(5): 813-15
  • Friedrik P. Wikman, Ming-Lan Lu, Thomas Thykjaer, Sanne H. Olesen, Lars D. Andersen, Carlos Cordon-Cardo, and Torben F. Ørntoft (2000). Evaluation of the Performance of a p53 Sequencing Microarray Chip Using 140 Previously Sequenced Bladder Tumor Samples. Clinical Chemistry 46(10): 1555-1561.

Resume

Research Experience

1/2008 – Employed as Postdoctoral Research Fellow under Dr. Ernst Schönbrunn, PhD., Drug Discovery Dept., H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

4/2006 – 12/2007 Associated with the H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida as an International Visiting Research Scholar on the project “Identification and characterization of novel tumor-associated genes in human colorectal cancer”. Mentor: Dr. Timothy Yeatman, M.D., F.A.C.S.

3/2006 – 12/2007 Employed as a Postdoctoral Research Fellow at Clinical Institute, Aarhus University Hospital, Skejby Sygehus, funded by the Danish Cancer Society. Mentor: Professor Torben F. Ørntoft, MD, DMSci.

10/2005 – 2/2006 Employed as a Research Assistant at Clinical Institute, Aarhus University Hospital, Skejby Sygehus. Supervisor: Dr. Karin Birkenkamp-Demtröder, Ph.D.

1/2002 – 6/2002 Employed as a Research Assistant at Institute for Experimental Clinical Research, Dept. of Clinical Biochemistry, Aarhus University Hospital, Skejby Sygehus. Supervisor: Dr. Karin Birkenkamp-Demtröder, Ph.D.

8/2001 – 12/2001 Employed as a Research Assistant at Molecular Diagnostic Laboratory, Dept. of Clinical Biochemistry, Aarhus University Hospital, Skejby Sygehus. Supervisor: Dr. Karin Birkenkamp-Demtröder, Ph.D.

 

Olesen Sanne