Frank Marsilio

Frank Marsilio

Research Associate

Protein chemistry, Biochemistry/p>

Email: frank.marsilio@moffitt.org

Frank is now working in the Moffitt High Throughput Screening core facility.

Publications

  • Kowalchick, J.E., Leiting, B., Pryor, K.D., Marsilio, F., Wu, J.K., He, H., Lyons, K.A., Eiermann,G.J., Petrov, A., Scapin, G., Patel, R.A., Thornberry, N. A., Weber, A. E., and Kim, D. (2007) Design, synthesis, and biological evaluation of triazolopiperazine-based B-amino amides as potent,orally active dipeptidyl peptidase IV (DPP-4) inhibitors. Bioorganic & Medicinal Chemistry Letters 17, 5934-5939.
  • Chen, P., Caldwell, C.G., Mathvink, R.J., Leiting, B., Marsilio, F., Patel, R.A., Wu, J.K., He, H., Lyons, K.A., Thornberry, N. A., and Weber, A.E., (2007) Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes. Bioorganic & Medicinal Chemistry Letters 17, 5853-5857.
  • Xu, J., Wei, L., Mathvink, R., Edmondson, S.D., Eiermann, G.J., He, H., Leone, J.F., Leiting, B., Lyons, K.A., Marsilio, F., Patel, R.A., Patel, S.B., Petrov, A., Scapin, G., Wu, J.K., Thornberry, N.A., and Weber, A.E., (2006) Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase-IV inhibitors. Bioorganic & Medicinal Chemistry Letters 16, 5373-5377.
  • Xu, J., Wei, L., Mathvink, R., Edmondson, S.D., Mastracchio, A., Eiermann, G.J., He, H., Leone, J.F., Leiting, B., Lyons, K.A., Marsilio, F., Patel, R.A., Petrov, A., Wu, J.K., Thornberry, N.A., and Weber, A.E., (2006) Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors. Bioorganic & Medicinal Chemistry Letters 16, 1346-1349.
  • Xu, J., Wei, L., Mathvink, R., He, J., Park, Y.J., He, H., Leiting, B., Lyons, K.A., Marsilio, F., Patel, R.A., Wu, J.K., Thornberry, N.A., and Weber, A.E., (2005) Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 15, 2533-2536.
  • Kim, D., Wang, L., Beconi, M, Eiermann, G.J., Fisher, M.H., He, H., Hickey, G.H., Leiting, B., Lyons, K., Marsilio, F., McCann, M.E., Patel, R.A., Petrov, A., Scapin, G., Patel, S.B., Roy, R.S., Wu, J.K., Wyvratt, M.J., Zhang, B.B., Thornberry, N.A., and Weber, A.E. (2005) (2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A potent, orally active dipeptidyl peptidase IV Inhibitor for the treatment of type 2 diabetes. Journal of Medicinal Chemistry 48, 141-151.
  • Ashton, W.T., Sisco, R.M., Dong, H., Lyons, K.A., He, H., Doss, G.A., Leiting, B., Patel, R.A., Wu, J.K., Marsilio, F., Thornberry, N.A., and Weber, A.E. (2005) Dipeptidyl peptidase IV inhibitors derived from B-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole. Bioorganic & Medicinal Chemistry Letters 15, 2253-2258.
  • Caldwell, C.G., Chen, P., He, J., Parmee, E.R., Leiting, B., Marsilio, F., Patel, R.A., Wu, J.K., Eiermann, G.J., Petrov, A., He, H., Lyons, K.A., Thornberry, N.A., and Weber, A.E. (2004) Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 14, 1265-1268.
  • Edmondson, S.D., Mastracchio, A., Beconi, M., Colwell Jr., L., Habulihaz, B., He, H., Kumar, S., Leiting, B., Lyons, K.A., Mao, A., Marsilio, F., Patel, R.A., Wu, J.K., Zhu, L., Thornberry, N.A., Weber, A.E., and Parmee, E.R. (2004) Potent and selective proline derived dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 14, 5151-5155.
  • Ashton, W.T., Dong, H., Sisco, R.M., Doss, G.A., Leiting, B., Patel, R.A., Wu, J.K., Marsilio, F., Thornberry, N.A., and Weber, A.E. (2004) Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 14, 859-863.
  • Brockunier, L.L., He, J., Colwell Jr., L.F., Habulihaz, B., He. H., Leiting, B., Lyons, K.A., Marsilio, F., Patel, R.A., Teffera, Y., Wu J.K., Thornberry, N.A., Weber A.E., and Parmee, E.R. (2004) Substituted piperazines as novel dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 14, 4763-4766.
  • Xu, J., Ok, H.O., Gonzales, E.L., Colwell, L.F., Habulihaz, B., He, H., Leiting, B., Lyons, K.A., Marsilio, F., Patel, R.A., Wu, J.K., Thornberry, N.A., Weber, A.E., and Parmee, E.R. (2004) Discovery of potent and selective beta-homophenylalanine based dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 14, 4759-4762.
  • Mastracchio, A., Parmee, E.R., Leiting, B., Marsilio, F., Patel, R., Thornberry, N.A., Weber, A.E., and Edmondson, S.D. (2004) Heterocycle fused cyclohexylgycine derivatives as novel dipeptidyl peptidase-IV inhibitors. Heterocycles 62, 203-206.
  • Parmee, E.R., He, J., Mastracchio, A., Edmondson, S.D., Colwell, L., Eiermann, G., Feeney, W.P., Habulihaz, B., He, H., Kilburn, R., Leiting, B., Lyons, K., Marsilio, F., Patel, R.A., Petrov, A., Di Salvo, J., Wu, J.K., Thornberry, N.A. and Weber, A.E. (2003) 4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 14, 43-46.
  • Leiting, B., Pryor, K.D., Wu, J.K., Marsilio, F., Patel, R.A., Craik, C.S., Ellman, J.A., Cummings, R.T., and Thornberry, N.A. (2003) Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. The Biochemical Journal 371, 525-532.
  • Yan, Y., Munshi, S., Li, Y., Pryor, K.D., Marsilio, F., Leiting, B. (1999) Crystallization and preliminary X-ray analysis of the Escherichia coli UDP-MurNAc-tripeptide D-alanyl-D-alanine-adding enzyme (MurF). Acta Crystallographica D55, 2033-2034.
  • Wong, K.K., Kuo, D.W., Chabin, R.M., Fournier, C., Gegnas, L.D., Waddell, S.T., Marsilio, F., Leiting, B., and Pompliano, D. (1998) Engineering a cell-free murein biosynthetic pathway: combinatorial enzymology in drug discovery. Journal of the American Chemical Society 120(51):13527-13528.
  • Leiting, B., Marsilio, F., and O’Connell, J.F. (1998) Predictable deuteration of recombinant proteins expressed in Escherichia coli. Analytical Biochemistry 265, 351-355.
  • Chang, C.H., Rickes, E.L., Marsilio, F., McGuire, L., Cosgrove, S., Taylor, J., Chen, H., Clark, J.N., Smith, R.G., DeVita, R.J., Schoen, W., Wyvratt Jr., M., and Hickey, G.J. (1995) Activity of a Novel Nonpeptidyl Growth Hormone Secretagogue, L-700,653, in swine. Endocrinology 136(3): 1065-1071.
  • Hickey, G.J., Chang, C.H., Marsilio, F., Trimboli, W., and Rickes, E.L. (1993) Effects of prednisone on dermal responses in flea-sensitized dogs. Veterinary Dermatology 4(2):71-77.
  • Almog, R., Marsilio, F., and Berns, D.S. (1988) Interactions of c-phycocyanin with lipid monolayers under nitrogen and in the presence of air. Archives of Biochemistry and Biophysics 260(1):28-36.

 

Frank Marsilio