Structure-Based Inhibitor Design, Synthesis, and Chemical Biology

JI Research Group 

News & Highlights

Ji Group is Looking for New Postdoc Fellows

POSTDOCTORAL POSITION available immediately for the design and synthesis of selective small-molecule inhibitors of protein–protein interactions. Successful candidates must have a PhD in medicinal chemistry or synthetic organic chemistry. Strong background and experience in medicinal chemistry and/or organic synthesis is essential. Experience in relevant areas including medicinal chemistry and/or natural product synthesis is desirable. Submit CV and statement of research experience via email to Dr. Haitao (Mark) Ji (Haitao.Ji@moffitt.org). Dr. Ji and the research team are in the Department of Drug Discovery (https://www.moffitt.org/research-science/divisions-and-departments/basic-science/drug-discovery/) and the Chemical Biology and Molecular Medicine Program (https://moffitt.org/research-science/research-programs/chemical-biology-and-molecular-medicine/). Recommendation letters will be requested when needed. Moffitt Cancer Center & Research Institute is an NCI-Designated Comprehensive Cancer Center. The starting salary for the postdoctoral fellows in Ji group meets the NIH standard of $47,484 + benefits.

Ji Group is Looking for New Postdoc Fellows

POSTDOCTORAL POSITION available for cancer biochemistry and chemical biology studies. We are looking for enthusiastic, highly self-motivated Ph.D. and/or M.D. fellows with strong laboratory skills in biochemistry and structural biology. The project involves the determination and characterization of highly selective small-molecule inhibitors for the crucial signaling pathways that are linked to tumorigenesis. Our ultimate goal is to provide novel targeted therapies for cancer. Submit CV and statement of research experience via email to Dr. Haitao (Mark) Ji (Haitao.Ji@moffitt.org).  Dr. Ji and the research team are in the Department of Drug Discovery (https://www.moffitt.org/research-science/divisions-and-departments/basic-science/drug-discovery/) and the Chemical Biology and Molecular Medicine Program (https://moffitt.org/research-science/research-programs/chemical-biology-and-molecular-medicine/). Recommendation letters will be requested when needed. Moffitt Cancer Center & Research Institute is an NCI-Designated Comprehensive Cancer Center. The starting salary for the postdoctoral fellows in Ji group meets the NIH standard of $47,484 + benefits.

Kevin's J. Med. Chem. paper published. This paper is featured as ACS Editors' Choice!

Teuscher, Kevin B.; Zhang, Min; Ji, Haitao. A versatile method to determine the cellular bioavailability of small-molecule inhibitors. Journal of Medicinal Chemistry 2017, 60 (1), 157–169.

This paper is also recommended by F1000 faculty. Click the icon below to read the F1000 faculty recommendation.

Access the recommendation on F1000Prime

Ji Group Joined the Moffitt Cancer Center

Ji Lab has moved to the H. Lee Moffitt Cancer Center & Research Institute in Florida on August 1, 2016. The lab is located on the fourth floor of the Moffitt Research Center (MRC), and the room number is MRC4029B. Ji Lab will develop new tools/techniques for the rational design of protein-protein interaction (PPI) inhibitors and the application of newly developed tools/techniques to discover potent and selective PPI inhibitors.

Dr. Ji Received the Susan G. Komen Career Catalyst Research Grant!

This three-year research grant allows the Ji lab to develop selective small-molecule inhibitors for the beta-catenin/Tcf protein-protein interaction. The grant starts on September 1, 2016.

Ji Group Received the First Patent for Their Invention

Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions. US 9,284,299 B2.

Jack's ACS Medicinal Chemistry Letters Paper Published

Wisniewski, John A.; Yin, Jinya; Teuscher, Kevin B.; Zhang, Min; Ji, Haitao. Structure-based design of 1,4-dibenzoylpiperazines as β-catenin/B-cell lymphoma 9 protein–protein interaction inhibitors. ACS Medicinal Chemistry Letters 2016, 7 (5), 508–513.

Yongqiang's Chemical Science Paper Published

Zhang, Yongqiang; Teuscher, Kevin B.; Ji, Haitao. Direct α-heteroarylation of amides (α to nitrogen) and ethers through a benzaldehyde-mediated photoredox reaction. Chemical Science 2016, 7 (3), 2111–2118.

Logan's JACS Paper Published

Hoggard, Logan R.; Zhang, Yongqiang; Zhang, Min; Panic, Vanja; Wisniewski, John A.; Ji, Haitao. Rational Design of selective small-molecule inhibitors for β-catenin/B-cell lymphoma 9 protein–protein interactions. J. Am. Chem. Soc. 2015, 137 (38), 12249–12260.

Leon's J. Med. Chem. Paper Published

Catrow, J. Leon; Zhang, Yongqiang; Zhang, Min; Ji, Haitao. Discovery of selective small-molecule inhibitors for the β-catenin/T-cell factor protein–protein interaction through the optimization of the acyl hydrazone moiety. J. Med. Chem. 2015, 58 (11), 4678–4692.

Protocol for Fragment Hopping Published

Teuscher, Kevin B.; Ji, Haitao. Protocol for Fragment Hopping, in Methods in Molecular Biology, 2015, volume 1289, pp 57–73

Assay Peper for Catenin/B-Cell Lymphoma 9 Inhibitors Published

Zhang, Min; Wisniewski, John A.; Ji, Haitao. AlphaScreen Selectivity Assay for β-Catenin/B-Cell Lymphoma 9 Inhibitors. Analytical Biochemistry 2015, 469, 43–53.

First Review Paper Published

Wenxing, Guo; John A. Wisniewski; Ji Haitao. Hot Spot-Based Design of Small-Molecule Inhibitors for Protein–Protein Interactions. Bioorganic & Medicinal Chemistry Letters, 2014, 24 (11), 2546–2554.

Undergraduate Research Presentations

Four undergraduate students (Sami Crouch, Danny Powell, Jessica Bones and Nina Eckstein) presented their works to academic feilds.

Click to see the pictures and read more details

DOD CDMRP Breast Cancer Research Grant

Dr. Ji received the Department of Defense (DOD) Congressionally Directed Medical Research Programs (CDMRP) Breast Cancer Research Program Breakthrough Award. This three-year grant starts in the summer of 2014.

Fourth Paper Published

Huang, Zheng; Zhang, Min; Burton, Shawn D.; Katsakhyan, Levon N.; and Ji, Haitao. Targeting the Tcf4 G13ANDE17 Binding Site to Selectively Disrupt β-Catenin/T-Cell Factor Protein–Protein Interactions, ACS Chemical Biology, 2014, 9 (1), 193–201.

Highlight : Paper Recommended by the F1000 Faculty

Rational design of small-molecule inhibitors for β-catenin/T-cell factor protein-protein interactions by bioisostere replacement, ACS Chemical Biology, 2013, 8 (3), 524–529, has been recommended by the F1000 Faculty. Click the icon below to read the recommendation.

F1000Prime Recommended

Third Paper Published

Zhang, Min; Catrow, J. Leon and Ji Haitao; High-Throughput Selectivity Assays for Small-Molecule Inhibitors of β-Catenin/T-Cell Factor Protein-Protein Interactions. ACS Medicinal Chemistry Letters, 2013, 4 (2), 306–311.

Second Paper Published

Yu, Binxun; Huang, Zheng; Zhang, Min; Dillard, Darren R. and Ji, Haitao; Rational Design of Small-Molecule Inhibitors for β-Catenin/T-Cell Factor Protein-Protein Interactions by Bioisostere Replacement. ACS Chemical Biology, 2013, 8 (3), 524–529.

Science Day

Dr. Ji gave a presentation on Computer-Aided Drug Design on University of Utah Science Day. Click to view pictures. 

Young investigator Award

05/15/2012: Dr. Ji won the Pulmonary Fibrosis Foundation Research Fund to Cure PF-Young investigator Award.

First Paper Published

Min Zhang, Zheng Huang, Binxun Yu, Haitao Ji. New Homogeneous High-Throughput Assays for Inhibitors of beta-Catenin/Tcf Protein-Protein Interaction. Analytical Biochemistry, 2012, 424, 57–63.

First Publication

Our first publication, a book chapter, titled "Fragment-Based Drug Design: Considerations for Good ADME Properties" has been published as Chapter 11 (pp 417-485) of ADMET for Medicinal Chemists: A Practical Guide (eds K. Tsaioun and S. A. Kates), 2011 by John Wiley & Sons, Inc. It is currently available.

Events

2014 Jun. Group trip to Moab. See more photos.

2013 Aug. End of summer BBQ in Millcreek Canyon! More photos

2012 Jun. Group picnic giving welcome to new members doing summer research. See photos

2012 Apr. As Toni and Anne are going back to Germany, Michelle is graduating soon,. Mark hosted a BBQ party. More photos