Find our articles on PubMED

  1. Lee SB, Sellers B, DeNicola G. The regulation of NRF2 by nutrient responsive signaling and its role in anabolic cancer metabolism. Antioxid Redox Signal. 2017 Sep 13. [Epub ahead of print]
  2. Permuth JB, Choi JW, Chen DT, Jiang K, DeNicola G, Li JN, Coppola D, Centeno BA, Magliocco A, Balagurunathan Y, Merchant N, Trevino JG, Jeong D. A pilot study of radiologic measures of abdominal adiposity: weighty contributors to early pancreatic carcinogenesis worth evaluating? Cancer Biol Med. 2017 Feb;14(1):66-73.
  3. Chio II, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee E, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia J, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA. NRF2 mediates redox-dependent mRNA translation and tumor maintenance in pancreatic cancer. 2016. Aug 11;166(4):963-76.
  4. Moon JS, Stout-Delgado H, DeNicola GM, Koo MJ, Rooney KT, Yoon JH, Ryter SW, Nakahira K, Choi AM. NOX4-dependent fatty acid oxidation regulates NLRP3 inflammasome activation. Nature Medicine. 2016. Sep;22(9):1002-12.
  5. DeNicola GM and Harris IA. Making sense of reAKTive oxygen species. Cell Death and Differentiation. Aug;23(8):1269-70.
  6. Mullarky E, Lucki NN, Zavareh RB, Anglin J, Gomes AP, Nicolay BN, Wong JCY, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, Lyssiotis CA, Lairson LL, Cantley Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. PNAS. 2016 Feb 1. Pii: 201521548. [Epub ahead of print]
  7. DeNicola GM and Cantley LC. Cancer’s fuel choice: new flavors for a picky eater. Review. Molecular Cell. 2015 Nov 19;60(4):514-23. 
  8. DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Tang H, Xie Y, Asara JM, Huffman KE, Witsuba II, Minna JD, DeBerardinis RJ, and Cantley LC. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nature Genetics. Dec;47(12):1475-81. doi: 10.1038/ng.3421.
  9. DeNicola GM, Karreth FA, Adams DA, Wong C. Transposon-mediated insertional mutagenesis: getting the jump on cancer. Review. Genome Biology. Oct 19;16(1):229. doi: 10.1186/s13059-015-0794-y.
  10. Moon JS, Hisata S, Park MA, DeNicola GM, Ryter SW, Nakahira K, Choi AM. mTORC1 induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation. Cell Reports. 2015. Jul 7;12(1):102-15.
  11. Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf G, Bell EL, Shim H, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, DeNicola GM, Song J, Brown V, Signoretti S, and Cantley LC. Deletion of Phosphatidylinositol-5-phosphate 4-Kinases results in impaired growth of TP53-/- tumors. Cell. 2013 Nov 7;155(4):844-57.
  12. Gopinathan A, DeNicola GM, Frese KK, Cook N, Karreth FA, Mayerle J, Lerch MM, Reinheckel T, Tuveson DA. Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice. 2012 Jun;61(6)877-84.
  13. Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, Krauthammer M, Halaban R, Provero P, Adams DJ, Tuveson DA, Pandolfi PP. In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. 2011 Oct 14;147(2):382-95.
  14. Caldwell ME, DeNicola GM, Martins CP, Jacobetz MA, Maitra A, Hruban R, Tuveson DA. Cellular features of senescence during the evolution ductal pancreatic cancer. 2012 Mar 22;31(12)1599-608.
  15. Karreth FA, Frese KK, DeNicola GM, Baccarini M, and Tuveson DA. C-Raf is required for the initiation of lung cancer by K-RasG12D. Cancer Discov. 2011 Jul;1(2):128-136.
  16. DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, and Tuveson DA. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. 2011 Jul 6;475(7354):106-9.
    • Highlighted in Nature. 2011 Jul 7;475(7354):43-4
    • Highlighted in Nature Reviews Cancer. 2011 Sep;11(9):622-3
    • Highlighted in Science Signaling. 2011 July 
12; 4(181):ec192
    • Highlighted in Pigment Cell Melanoma Research. 2011 Dec;24(6):1078-9
    • Highlighted in New Scientist. 2011 July 06; 2820
    • Highlighted in Chemical & Engineering News. 2011. July 11; 89(28):3
  17. Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L, Warren A, Scott H, Madhu B, Sharma N, Bon H, Zecchini V, DeNicola GM, Mathews N, Osborne M, Hadfield J, MacArthur S, Adryan B, Grigorenko E, Lyons SK, Brindle KM, Griffiths J, Gleave ME, Rennie PS, Neal DE and Mills IG. The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J. 2011 May 20;30(13):2719-33.
    • Highlighted in EMBO J. 2011 Jul 6;30(13):2516-7.
  18. Karreth FA, DeNicola GM, Winter SP, Tuveson DA. C-Raf inhibits MAPK activation and transformation by B-Raf(V600E). Mol Cell. 2009 Nov 13;36(3):477-86.  
  19. DeNicola GM, Tuveson DA. RAS in cellular transformation and senescence. Eur J Cancer. 2009 Sep;45 Suppl 1:211-6. Review.
  20. Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. 2009 Jun 12;324(5933):1457-61.
    • Highlighted in Science. 2009 Jun 12;324(5933):1400-1.
  21. Denicola G, Tuveson DA. VAV1: a new target in pancreatic cancer? Cancer Biol Ther. 2005 May;4(5):509-11. Review.