Morad Lab
Morad Lab
Morad G, Damania A, Melendez B, Singh BB, Veguilla FJ, Hoballah YM, Sahasrabhojane PV, Wong MC, Soto RA, Wani K, Lazcano RN, Ingram DR, Chelvanambi M, Johnson SB, Dimitriou F, Gupta P, Oberai S, Zal A, Doss P, Chang C, Jamal MA, Hayase E, Watho C, Norberg L, Jenkins SL, Nass S, Gumin J, Long L, Tang J, Bradely G, Prasad M, Dono A, Pichardo-Rojas PS, Ballester LY, Losh JS, Liang J, Huo L, Nielsen DC, Parker Kerrigan BC, Brastianos PK, Folkes NW, Jenq RR, Gomez-Manzano C, Huse JT, Davies MA, Lazar AJ, Bhat K, Tandon N, Esquenazi Y, Peterson CB, Puduvalli VK, Lang FF, Bullman S, Ajami NJ, Ferguson SD, Wargo JA. Microbial signals in primary and metastatic brain tumors. Nat Med. 2025 Nov;31(11):3675-3688.
Link: https://pubmed.ncbi.nlm.nih.gov/41238915/
Hadjigeorgiou AG, Harkos C, Mishra AK, Morad G, Johnson SB, Ajami NJ, Wargo JA, Munn LL, Stylianopoulos T, Jain RK. Mathematical Modeling and Association Analysis Deciphers the Impact of the Gut Microbiome on Cancer Immunotherapy. Cancer Res. 2025 May 29. doi: 10.1158/0008-5472.CAN-24-2232.
Link: https://pubmed.ncbi.nlm.nih.gov/40439571/
Massara M, Ballabio M, Dolfi B, Morad G, Wischnewski V, Lamprou E, Lourenco J, Claudinot S, Gallart-Ayala H, Méndez RS, Kauzlaric A, Fournier N, Damania AV, Wong MC, Ivanisevic J, Ajami NJ, Wargo JA, Joyce JA. The bacterial microbiome modulates the initiation of brain metastasis by impacting the gut-to-brain axis. iScience. 2025 Jan 22;28(2):111874.
Link: https://pubmed.ncbi.nlm.nih.gov/39995854/
Park JS, Gazzaniga FS, Wu M, Luthens AK, Gillis J, Zheng W, LaFleur MW, Johnson
SB, Morad G, Park EM, Zhou Y, Watowich SS, Wargo JA, Freeman GJ, Kasper DL, Sharpe AH. Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature. 2023 May;617(7960):377-385.
Link: https://pubmed.ncbi.nlm.nih.gov/37138075/
Morad G, Helmink BA, Sharma P, Wargo JA. Hallmarks of response, resistance, and toxicity to immune checkpoint blockade. Cell. 2021 Oct 14;184(21):5309-5337.
Link: https://pubmed.ncbi.nlm.nih.gov/35120665/
Spencer CN, McQuade JL, Gopalakrishnan V, McCulloch JA, Vetizou M, Cogdill AP, Khan MDAW, Zhang X, White MG, Peterson CP, Wong MC, Morad G, …, Wargo JA. Dietary fiber and probiotics impact the gut microbiome and melanoma immunotherapy response. Science. 2021 Dec 24;374(6575):1632-1640.
Link: https://pubmed.ncbi.nlm.nih.gov/34941392/
Andrews MC, Duong CPM, Gopalakrishnan V, Iebba V, Chen WS, Derosa L, Khan MAW, Cogdill AP, White MG, Wong MC, Ferrere G, Fluckiger A, Roberti MP, Opolon P, Alou MT, Yonekura S, Roh W, Spencer CN, Curbelo IF, Vence L, Reuben A, Johnson S, Arora R, Morad G, …, Wargo JA. Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade. Nat Med. 2021 Aug;27(8):1432-1441.
Link: https://pubmed.ncbi.nlm.nih.gov/34239137/
Guo P, Bussato S, Huang J, Morad G, Moses M. A facile magnetic extrusion method for preparing endosome-derived vesicles for cancer drug delivery. Adv Funct Mater. 2021
Link: https://pubmed.ncbi.nlm.nih.gov/34924915/
French SL, Butov KR, Allaeys I, Canas J, Morad G, Davenport P, Laroche A, Trubina NM, Italiano JE, Moses MA, Sola-Visner M, Boilard E, Panteleev MA, Machlus KR. Platelet- derived Extracellular Vesicles Infiltrate and Modify the Bone Marrow During Inflammation. Blood Adv. 2020 Jul 14;4(13):3011-3023.
Link: https://pubmed.ncbi.nlm.nih.gov/32614966/
Morad G, Daisy CC, Otu HH, Dillon ST, Moses MA. Cdc42-dependent transfer of miR301 from breast cancer-derived extracellular vesicles regulates the matrix modulating ability of astrocytes at the blood brain barrier. Int J Mol Sci. 2020, 21(11), 3851
Link: https://pubmed.ncbi.nlm.nih.gov/32481745/
Morad G, Carman CV, Hagedorn EJ, Perlin JR, Zon LI, Mostafaoglu N, Park TE, Ingber DE, Daisy CC, Moses MA. Tumor-derived extracellular vesicles breach the intact blood-brain barrier via transcytosis. ACS Nano. 2019 Dec 24;13(12):13853-13865.
Link: https://pubmed.ncbi.nlm.nih.gov/31479239/
Morad G and Moses MA. Brainwashed by extracellular vesicles: The role of extracellular vesicles in primary and metastatic brain tumor microenvironments. J Extracell Vesicles. 2019 Jun 27;8(1):1627164.
