• Cancer Physiology
  • Breast Oncology
  • Cancer Biology and Evolution Program
  • See publications

Andriy Marusyk, PhD

Tumors are mini eco-systems, where evolving populations of genetically and phenotypically heterogeneous malignant cells are engaged in a network of reciprocal interactions with multiple normal cell types as well as with non-cellular components of tumor micro and macro environment. Research over recent decades shed light on molecular pathways essential for cancer cell survival, leading to development of multiple novel therapeutic approaches. Unfortunately, almost in all cases anti-cancers therapies provide only a temporary success, as tumors eventually relapse owing to outgrowth of therapy-resistant phenotypes. Preventing and limiting this outgrowth cannot be achieved only by focusing on proximal molecular mechanisms of resistance. We also need to develop adequate level of understanding of evolutionary dynamics, a knowledge that is mostly lacking. The main focus of research in my lab is filling this gap through development of experimental models that allow characterization and quantification of dynamics of populations of cancers cells under base-like conditions as well as under the stress of anti-cancer therapies.  Another major research effort is centered on characterization of interactions between malignant cells and tumor associated fibroblasts with the aim of developing means to overcome stromal resistance to anti-cancer therapies.

Education & Training

  • Taras Shevchenko National University, MS - Biology, Cell Biology and Genetic Engineering
  • University of Colorado , PhD - Biophysics and Molecular Genetics
  • University of Colorado Health Sciences Center, Postdoctoral Fellow
  • Postdoctoral Felllow - Dana Farber Cancer Institute & Harvard Medical School

 

Daria Miroshnychenko, Ph.D
Daria.Mrioshnychenko@Moffitt.org

 

 

Robert Vander Velde 
Robert.VanderVelde@Moffitt.org 

 

Bina Desai
Bina.Desai@Moffitt.org 

Viktoriya Marusyk
Lab Manager
Viktoriya.Marusyk@Moffitt.org 

Fiorella Lanatta
Grants Administrator Associate
Fiorella.Lanatta@Moffitt.org

Rachel Snayd
Grants Administrator I
Rachel.Snayd@Moffitt.org