Welcome to Dr. Gillies Lab

Latest News

Grant Update

Drs. Smitha Pillai and Robert Gillies have received a Florida Biomedical Research Program grant focusing on "Targeting the lipogenic phenotype induced by extracellular acidosis in breast cancer" 



Conference on Cancer Evolution and Ecology:


Location: Don CeSar, St. Pete Beach, Florida

Date: 22nd – 25th,  May 2018

Moffitt Cancer Center recently created the Center for Evolutionary Therapy (CET), to develop and deploy the next generation of personalized cancer therapy through the integration of predictive mathematical models, patient data and evolutionary principles.

In order to celebrate our new center, we would like to bring together a small group of key theoretical, experimental and clinical colleagues to share and discuss our diversity of approaches to treat the complex evolving system that is cancer. This meeting will be hosted in the beautiful and historic Don CeSar Hotel directly on the beach in St. Petersburg, on Tuesday May 22nd – Friday May 25th, 2018 (http://www.doncesar.com).



Radiomics Workshop 2018

The annual Radiomics workshop sponsored by Moffitt will be held Oct. 15-16 at the Hyatt Regency Clearwater Beach, 301 S Gulfview Blvd, Clearwater, FL 33767. More information to be released soon.


SRB Mouse Breeding Colonies


Robert J. Gillies, PhD.

Robert J. Gillies and his lab are focused on understanding cancers as complex, heterogeneous and dynamic systems. Along with his long-time collaborator, Robert A. Gatenby, they share a core belief that, due to genomic plasticity and microenvironmental heterogeneity, cancers can only be understood through the lens of Darwinian Evolution. Dr. Gillies is an experimentalist whose work spans molecular, cellular, animal models, and image analytics. He is the Martin Silberger Chair of Cancer Physiology, Director of the Center of Excellence in Cancer Imaging and Technology, and Scientific Director of the Small Animal Imaging Lab, SAIL. 


May 2017, Cancer Research cover, from Arig Ibrahim-Hashim, Robert J. Gillies et al. "Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution


Quantitative Imaging (QI)

Quantitative Imaging is an indispensable approach to study intratumoral heterogeneity. Dr. Gillies' group develops and applies Image Analytics to histological and radiological images to investigate the spatial relationships of cells and microenvironments in clinical and pro-clinical tumors.

Projects include:

Tumor pH

Solid tumors are acidic due to elevated glycolysis combined with poor perfusion. Dr. Gillies has developed methods to image tumor pH, and study the causes and consequence of this acidity. Recent focus has been on developing methods to interfere with tumor acidosis for improving therapy in the clinic.

Projects include:


Physical Sciences in Oncology Center at Moffitt Cancer Center


Integrated Mathematical Oncology at Moffitt Cancer Center


Upcoming Events

  • To Be Announced