The World Molecular Imaging Society (WMIS) awarded the 2018 Gold Medal Award to Dr. Robert J. Gillies, PhD, Moffitt Cancer Center, for his revolutionary contributions to the field. Dr. Gillies accepted the Gold Medal at the 11th annual World Molecular Imaging Congress (WMIC), September 12-15, 2018 in Seattle, WA, USA among over 1,200 of his peers and colleagues. The title of his talk was "Quantitative Imaging in the Post-Genomic Era"
Also from the WMIC, Congratulations to Ilke Tunali for being one of the three finalist of Young Investigator Award for his study “Radiomics and clinical predictors of disease progression among non-small cell lung cancer patients treated with checkpoint inhibitors”.
Congratualtions Shonagh Russell (PhD student in Dr. Gillies Lab)! Shonagh has received the F99/K00 funding award from the NCI
"I have been a PhD student at Moffitt Cancer Center for four years now in the Cancer Biology PhD program under the mentorship of Dr Gillies. During this time, I have had tremendous support from my colleagues, friends, and mentors who have enabled me to successfully apply for and be awarded the NCI Predoctoral to Postdoctoral Fellow Transition Award (F99/K00). My grant titled “Understanding metabolic vulnerabilities in cancer and the impact the tumor microenvironment has on cancer progression.” will enable me to answer fundamental questions during my PhD about proton producing proteins and their role in, not only driving metabolism and metastasis in cancer but how their activity causes a proton deficit leading to upregulation of glycolysis. Secondly, this grant will enable me to transition into a post-doc where I will gain insight into small cell lung cancer metabolism and how this can be targeted therapeutically. I believe further understanding of cancer metabolism can benefit a wide range of patients due to applying to numerous cancer types and genotypes and the more people that can be helped, the better."
-Shonagh Russell, PhD student
Shonagh is Moffitt's very first F99/K00 awardee!
Congratulations, members from Dr. Gillies lab won the Abstract Award for the presentation entitled: "Co-registration of MRI and histological habitats in pre-clinical tumor models" in the MR of Cancer Study Group business meeting during ISMRM 2018 in Paris. Authors: Bruna V. Jardim-Perassi, Suning Huang, William Dominguez-Viqueira, Epifanio Ruiz, Mikalai Budzevich, Jan Poleszczuk, Marilyn Bui, Robert Gillies and Gary Martinez
Drs. Smitha Pillai and Robert Gillies have received a Florida Biomedical Research Program grant focusing on "Targeting the lipogenic phenotype induced by extracellular acidosis in breast cancer"
Radiomics Workshop 2018
The annual Radiomics workshop sponsored by Moffitt will be held Oct. 15-16 at the Hyatt Regency Clearwater Beach, 301 S Gulfview Blvd, Clearwater, FL 33767. More information to be released soon.
Robert J. Gillies and his lab are focused on understanding cancers as complex, heterogeneous and dynamic systems. Along with his long-time collaborator, Robert A. Gatenby, they share a core belief that, due to genomic plasticity and microenvironmental heterogeneity, cancers can only be understood through the lens of Darwinian Evolution. Dr. Gillies is an experimentalist whose work spans molecular, cellular, animal models, and image analytics. He is the Martin Silberger Chair of Cancer Physiology, Director of the Center of Excellence in Cancer Imaging and Technology, and Scientific Director of the Small Animal Imaging Lab, SAIL.
May 2017, Cancer Research cover, from Arig Ibrahim-Hashim, Robert J. Gillies et al. "Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution"
Gillies Lab at the Moffitt PSOC Site Visit
(From Moffitt MRI Signals published August 15, 2018)
Drs. Damaghi, Gillies, Cleveland & Colleagues
Research Scientist, Mehdi Damaghi, in Gillies lab was co-lead author a paper recently published inNature Communications that utilized a systems analysis of intracellular pH vulnerabilities for cancer therapy. The team, which included Dr. Bob Gillies, and John Cleveland, developed a computational methodology that explores how intracellular pH (pHi) can modulate metabolism. Experimental testing of the novel strategy revealed that it is particularly effective against aggressive phenotypes. The study suggests essential roles of pHi in cancer metabolism and provides a conceptual and computational framework for exploring pHi roles in other biomedical domains. Moffitt's Molecular Genomics and Analytical Microscopy cores were also utilized.
Moffitt researchers Drs. Robert Gillies, Joel Brown, Sandy Anderson, and Robert Gatenby have published in Nature Reviews Cancer.
Their opinion posits that temporal changes in blood flow are commonly observed in malignant tumours, but the evolutionary causes and consequences are rarely considered. The authors propose that stochastic temporal variations in blood flow and microenvironmental conditions arise from the eco-evolutionary dynamics of tumour angiogenesis in which cancer cells, as individual units of selection, can influence and respond only to local environmental conditions.
Temporal variations in intratumoural blood flow, which occur through the promotion of cancer cell phenotypes that facilitate both metastatic spread and resistance to therapy, may have substantial clinical consequences.
Quantitative Imaging is an indispensable approach to study intratumoral heterogeneity. Dr. Gillies' group develops and applies Image Analytics to histological and radiological images to investigate the spatial relationships of cells and microenvironments in clinical and pro-clinical tumors.
Solid tumors are acidic due to elevated glycolysis combined with poor perfusion. Dr. Gillies has developed methods to image tumor pH, and study the causes and consequence of this acidity. Recent focus has been on developing methods to interfere with tumor acidosis for improving therapy in the clinic.