Welcome to the Marusyk Lab!
The majority of advanced cancers remain lethal. Despite often spectacular initial responses to targeted and chemo therapies, cancers eventually relapse as they develop resistance to the drugs. Our mission is to understand the development of therapy resistance from eco-evolutionary angle, considering both changes occurring in tumor cells, as well as influences of tumor microenvironment. Then, we aim use this knowledge to design new therapeutic approaches, aimed at forestalling the ability of tumors to evolve resistance. To achieve these goals, we are using multi-prong integrative approaches combining experimental studies, mathematical modeling and clinical analyses.