Ruffell Lab

Research Articles

Coming Soon

El-Kenawi et al. • British Journal of Cancer 2019

Acidity Promotes Tumor Progression by Altering Macrophage Phenotype in Prostate Cancer

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de Mingo Pulido et al. • Cancer Cell 2018

TIM-3 Regulates CD103⁺ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer

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Review Articles

Gardner, de Mingo Pulido & Ruffell • Frontiers in Immunology 2020

Dendritic Cells and their Role in Immunotherapy

El-Kenawi, Hänggi & Ruffell • CSH Perspectives 2020

The Immune Microenvironment and Cancer Metastasis

DeNardo & Ruffell • Nature Reviews Immunology 2019

Macrophages as Regulators of Immunity and Immunotherapy

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Gardner & Ruffell • Trends in Immunology 2016

Dendritic Cells and Cancer Immunity

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de Mingo Pulido & Ruffell • Adv in Cancer Research 2015

Immune Regulation of the Metastatic Process: Implications for Therapy

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Ruffell & Coussens • Cancer Cell 2015

Macrophages and Therapeutic Resistance in Cancer

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Preview Articles

Hänggi & Ruffell • Cancer Cell 2019

Oncogenic KRAS Drives Immune Suppression in Colorectal Cancer

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Gardner & Ruffell • Immunity 2017

moDCs, Less Problems

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El-Kenawi & Ruffell • Cancer Cell 2017

Inflammation, ROS, and Mutagenesis

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Gardner & Ruffell • Nature Cell Biology 2017

Reducing Interferon'ce in Stem Cells

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Pilon-Thomas & Ruffell • Cancer Cell 2016

Tipping the Balancing ACT

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Collaborations

Trillo-Tinoco J, Sierra RA, Mohamed E, Cao Y, de Mingo-Pulido A, Gilvary D, Anadon CM, Costich TL, Wei S, Flores E, Ruffell B, Conejo-Garcia JR, & Rodiquez PC (in press) AMPKa1 intrinsically regulates the function and differentiation of tumor-related MDSC. Cancer Research.

Reddy JP, Atkinson RL, Larson R, Burks JK, Smith D, Debeb BG, Ruffell B, Creighton C, Bambhroliya A, Reuben J, Van Laere SJ, Krishnamurthy S, Symmans WF, Brewster A, Woodword WA (2018). Mammary stem cell and macrophage markers are enriched in normal tissue adjacent to inflammatory breast cancer. Breast Cancer Res. Treat. 171 (2): 283-293.

Betts CB, Pennock ND, Ruffell B, Schedin PJ. (2018) Mucosal immunity in the female murine mammary gland. J. Immunol. 201: 734-746.

Bergstrom CP, Ruffell B, Ho CMT, Higano CS, Garzotto M, Beer TM, Graff JN. (2017) Docetaxel and mitoxantrone prior to radical prostatectomy in men with high risk prostate cancer: Ten-year follow up and immune correlates. Anti-Cancer Drugs 28 (1): 120-126.

Wolfe AR, Trenton NJ, Debeb BG, Larson R, Ruffell B, Chu K, Hittelman W, Diehl M, Reuben JM, Ueno NT, Woodward WA. (2016) Mesenchymal stem cells and macrophages interact through IL-6 to promote inflammatory breast cancer in pre-clinical models. Oncotarget 7 (50): 82482-82492.

Zheng H, Zhao W, Bronk C, Massengill M, Yan C, Zie M, Noyes D, Yoder S, Massengill C, Martinez GV, Afzal R, Chen Z, Haura EB, Antonia SJ, Ruffell B, Beg AA. (2016) HDAC inhibitors enhance tumor immunogenicity and T cell infiltration and function to augment response to PD-1 immunotherapy. Clin. Cancer Res. 22 (16): 4119-4132.

Juric V, Ruffell B, Evason KJ, Che L, Hu J, Chen X, Bishop JM. (2015) Monocytes promote liver carcinogenesis in an oncogene-specific manner. J Hepatol. 64 (4): 881-890.

Wolfe AR, Debeb BG, Lacerda L, Larson R, Bambhroliya A, Huang X, Bertucci F, Finetti P, Birnbaum D, Van Laere S, Diagaradjan P, Ruffell B, Trenton NJ, Chu K, Hittelman W, Diehl M, Levental I, Ueno NT, Woodward WA. (2015) Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a. Breast Cancer Res Treat 154(3): 495-508.

Full list of Dr. Ruffell's publications

NCBI MyBibliography • Google Scholar • Scopus Database • ORCID Database