BCR Pathway inhibitor regulation of the CLL Microenvironment

We are studying the effects of clinically available BCR Pathway specific kinase inhibitors, PI3Ki and BTKi, and how they augment the regulatory microenvironments, specifically T-regs and MDSCs, involved in CLL preservaton.

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Role of HDAC6 in CLL

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HDAC11 in Myelopoiesis

Using our Knockout and eGFP dual Expression mouse models for HDAC11 we have identified HDAC11 present in several points of myeloid maturation. Further studies to identify the role that HDAC11 plays in the maturation are underway.

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