The Flores Lab

News & Views

	Collaboration with APIS Assay Technologies to assess the suitability of TROLL-2 and TROLL-3 as predictive biomarkers of cancer progression and their role as markers of chemotherapy response Triple Negative Breast Cancer First Target of Moffitt Cancer Center, APIS Collaboration APIS Assay Technologies and Moffitt Cancer Center sign Master Collaboration Agreement on lncRNA TROLL Biomarker assessment
	Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation Vermes, K. Moffitt Cancer Center Sees Breakthrough in Latest Pan-Cancer Analysis. BioSpace. 2020 Oct 20.
	TAp63-Regulated miRNAs Suppress Cutaneous Squamous Cell Carcinoma through Inhibition of a Network of Cell-Cycle Genes Parrales A. and Iwakuma T. TAp63-miRNA-AURKA Axis as a Therapeutic Target for Cutaneous Squamous Cell Carcinoma. Cancer Research. 2020 June 05. doi: 10.1158/0008-5472.CAN-20-1215
	∆Np63/DGCR8- Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer. Ferrarelli LK. Predictive biomarkers for HDAC inhibitor efficacy. Science Signaling. 2016 Jul 05. doi: 10.1126/scisignal.aah4647.
	IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. McCarthy N. Feed a cold, starve a tumor. Nature Reviews Cancer. 2014 Dec 11. doi: 10.1038/nrc3881. American Association for Cancer Research. Induction of Metabolic Reprogramming Suppresses p53-Null Tumor Growth. Cancer Discovery. 2014 Dec 04. doi: 10.1158/2159-8290.CD-RW2014-248.
	TAp63 is the master transcriptional regulator of lipid and glucose metabolism Burgess DJ. Metabolism: TAp63 tips the energy balance? Nature Reviews Cancer. 2012 Oct 18. doi: 10.1038/nrc3386.
	TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs Leslie M. Brothers in arms against cancer. Science. 2011 Mar 25. doi: 10.1126/science.331.6024.1551. Alderton GK. Tumor suppression: The burning issue of p63. Nature Reviews Cancer. 2010 Nov 24. doi: 10.1038/nrc2978. Valastyan S. and Weinberg RA. Metastasis suppression: The role of Dice(r). Genome Biology. 2010 Nov 30. doi: 10.1186/gb-2010-11-11-141. Faculty of 1000 – rated 8 (Laura Attardi, Ph.D., Associate Professor, Stanford University)
	DeltaNp63 transcriptionally regulates brachyury, a gene with diverse roles in limb development, tumorigenesis and metastasis Sinha S. Breaking into the Brachury world: ΔNp63 joins in. Cell Cycle. 2010 Jul 01. doi: 10.4161/cc.9.13.12238.
	TAp63 prevents premature aging by promoting adult stem cell maintenance Beaurdy VG and Attardi LD. SKP-ing TAp63: Stem Cell Depletion, Senescence and Premature Aging. Cell Stem Cell. 2009 Jul 02. doi: 10.1016/j.stem.2009.06.015.
	p63 and p73 are required for p53-dependent apoptosis in response to DNA damage Urist M. and Prives C. p53 leans on its siblings. Cancer Cell. 2002 May 01. doi: 10.1016/S1535-6108(02)00064-8. Mitchell A. Apoptosis: The p53 mafia. Nature Reviews Cancer. 2002 May 01. doi: 10.1038/nrc804. Faculty of 1000 – rated 6 (William Kaelin, M.D., Professor, Harvard Medical School, Dana Farber Cancer Institute)