Publications

2024

• Napoli, M., Deshpande, A. A., Chakravarti, D., Rajapakshe, K., Gunaratne, P. H., Coarfa, C., & Flores, E. R. (2024). Genome-wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses. Cancer Research Communications. 2024 Feb 1; 4(2), 264–278. https://doi.org/10.1158/2767-9764. PMID: 38165157. 

 

• Jinesh GG, Smallin MT, Mtchedlidze N, Napoli M, Lockhart JH, Flores ER, Brohl AS. C19MC drives nucleolar invasion of mitochondria and meiotic nuclear division in human cancers. iScience. 2024 Oct 10;27(11):111132. doi: 10.1016/j.isci.2024.111132. PMID: 39563898; PMCID: PMC11575172.

 

• Darville LNF, Lockhart JH, Putty Reddy S, Fang B, Izumi V, Boyle TA, Haura EB, Flores ER, Koomen JM. A Fast-Tracking Sample Preparation Protocol for Proteomics of Formalin-Fixed Paraffin-Embedded Tumor Tissues. Methods Mol Biol. 2024;2823:193-223. doi: 10.1007/978-1-0716-3922-1_13. PMID: 39052222.

 

• Flores ER, Sawyer WG. Engineering cancer's end: An interdisciplinary approach to confront the complexities of cancer. Cancer Cell. 2024 Jul 8;42(7):1133-1137. doi: 10.1016/j.ccell.2024.05.017. Epub 2024 Jun 6. PMID: 38848721.

 

• Napoli M, Deshpande AA, Chakravarti D, Rajapakshe K, Gunaratne PH, Coarfa C, Flores ER. Genome-wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses. Cancer Res Commun. 2024 Feb 1;4(2):264-278. doi: 10.1158/2767-9764.CRC-23-0358. PMID: 38165157; PMCID: PMC10832605.

2023

• Lockhart, J.H., Ackerman, H.D., Lee, K. et al. Grading of lung adenocarcinomas with simultaneous segmentation by artificial intelligence (GLASS-AI). npj Precision Oncology. 2023 July 18. doi: 10.1038/s41698-023-00419-3. PMID: 37464050.

 

• Pereira PLG, Flores ERM, Silva TPRD, Faria APV, Ribeiro EEN, Sato APS, Gomes LP, Matozinhos FP. Epidemiology of monkeypox notifications in the state of Minas Gerais, Brazil. Rev Bras Enferm. 2023 Oct 9;76(3):e20220598. doi: 10.1590/0034-7167-2022-0598. PMID: 37820161; PMCID: PMC10561937.

 

• Jinesh GG, Smallin MT, Mtchedlidze N, Godwin I, Napoli M, Hackel N, Phadke MS, Deshpande AA, Li X, Lockhart JH, Baldwin JR, Acevedo-Acevedo S, Gao Y, Reiser MA, Smalley KSM, Flores ER, Brohl AS. C19MC miRNA-520G induces SP100 antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma. Genes Dis. 2023 Apr 5;11(1):60-63. doi: 10.1016/j.gendis.2023.02.047. PMID: 37588194; PMCID: PMC10425800.

 

2022

• Napoli, M., Wu, S.J., Gore, B.L., Abbas, H., Lee K., Checker R., Dhar S., Rajapakshe K., Tan A.C., Lee M.G., Coarfa C., Flores E.R. ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer. Nature Communications. 2022 Feb 1. doi: 10.1038/s41467-022-28202-1. PMID: 35105868.

 

2021 

• Chitsazzadeh V, Nguyen TN, de Mingo Pulido A, Bittencourt BB, Du L, Adelmann CH, Ortiz Rivera I, Nguyen KA, Guerra LD, Davis A, Napoli M, Ma W, Davis RE, Rajapakshe K, Coarfa C, Flores ER, Tsai KY. miR-181a Promotes Multiple Protumorigenic Functions by Targeting TGFβR3. J Invest Dermatol. 2021 Dec 8. doi: 10.1016/j.jid.2021.09.040. PMID: 34890627. 

 

• Lee K, Lockhart JH, Xie M, Chaudhary R, Slebos RJC, Flores ER, Chung CH, Tan AC. Deep Learning of Histopathology Images at the Single Cell Level. Front Artif Intell. 2021 Sept 10. doi: 10.3389/frai.2021.754641. eCollection 2021. PMID: 34568816. 

 

• Napoli M, Deshpande AA, Flores ER. The Landmark Discovery That Paved the Way to a Mechanistic Understanding of P53 Gain of Function and Personalized Medicine. Cancer Research. 2021 Sep 1. doi: 10.1158/0008-5472.CAN-21-2382. PMID: 34470782. 

 

• Amit M, Liu C, Mansour J, Gleber-Netto FO, Tam S, Baruch EN, Aashiq M, El-Naggar AK, Moreno AC, Rosenthal DI, Glisson BS, Ferrarotto R, Wong MK, Tsai K, Flores ER, Migden MR, Silverman DA, Li G, Khanna A, Goepfert RP, Nagarajan P, Weber RS, Myers JN, Gross ND. Elective neck dissection versus observation in patients with head and neck cutaneous squamous cell carcinoma. Cancer. 2021 August 6. doi: 10.1002/cncr.33773.  PMID: 34358340. 

 

• Jinesh GG, Napoli M, Smallin MT, Davis A, Ackerman HD, Raulji P, Montey N, Flores ER, Brohl AS. Mutant p53s and chromosome 19 microRNA cluster overexpression regulate cancer testis antigen expression and cellular transformation in hepatocellular carcinoma. Scientific Reports. 2021 June 16. doi: 10.1038/s41598-021-91924-7. PMID: 34135394. 

 

• Xie M, Lee K, Lockhart JH, Cukras SD, Carvajal R, Beg AA, Flores ER, Teng M, Chung CH, Tan AC. TIMEx: tumor-immune microenvironment deconvolution web-portal for bulk transcriptomics using pan-cancer scRNA-seq signatures. Bioinformatics. 2021 April 26. doi: 10.1093/bioinformatics/btab244. PMID: 33901274.

 

• Wu HH, Wang B, Armstrong SR, Abuetabh Y, Leng S, Roa WHY, Atfi A, Marchese A, Wilson B, Sergi C, Flores ER, Eisenstat DD, Leng RP. Hsp70 acts as a fine-switch that controls E3 ligase CHIP-mediated TAp63 and ΔNp63 ubiquitination and degradation. Nucleic Acids Res. 2021 Mar 18. doi: 10.1093/nar/gkab081. PMID: 33619536. 

 

2020

• Justel FJ, Taboada ME, Flores EK, Galleguillos HR, Graber TA. Thermodynamic Model for the Design of a Process of Production of Copper Sulfate Pentahydrate from Copper Ores. ACS Omega. 2020 Nov 4. doi: 10.1021/acsomega.0c03615. PMID: 33225138. 

  

• Nguyen TN, Rajapakshe K, Nicholas C, Tordesillas L, Ehli EA, Davis CM, Coarfa C, Flores ER, Dickinson SE, Curiel-Lewandrowski C, Tsai KY. Integrative transcriptomic analysis for linking acute stress responses to squamous cell carcinoma development. Scientific Reports. 2020 Oct 14. doi: 10.1038/s41598-020-74051-7. PMID: 33057049.

 

• Napoli M, Li X, Ackerman HD, Deshpande AA, Barannikov I, Pisegna MA, Bedrosian I, Mitsch J, Quinlan P, Thompson A, Rajapakshe K, Coarfa C, Gunaratne PH, Marchion DC, Magliocco AM, Tsai KY, Flores ER. Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation.  Nature Communications. 2020 Oct 14. doi: 10.1038/s41467-020-18973-w. PMID: 33056990. 

 

• Min S, Oyelakin A, Gluck C, Bard JE, Song EC, Smalley K, Che M, Flores E, Sinha S, Romano RA. p63 and Its Target Follistatin Maintain Salivary Gland Stem/Progenitor Cell Function through TGF-β/Activin Signaling. iScience. 2020 Sep 2. doi: 10.1016/j.isci.2020.101524. PMID: 33056990. 

 

• Jinesh GG, Napoli M, Ackerman HD, Raulji PM, Montey N, Flores ER, Brohl AS. Regulation of MYO18B mRNA by a network of C19MC miRNA-520G, IFN-γ, CEBPB, p53 and bFGF in hepatocellular carcinoma. Scientific Reports. 2020 July 23. doi: 10.1038/s41598-020-69179-5. PMID: 32704163

 

• Bui NHB, Napoli M, Davis AJ, Abbas HA, Rajapakshe K, Coarfa C, Flores ER. Spatiotemporal Regulation of ΔNp63 by TGFβ-Regulated miRNAs Is Essential for Cancer Metastasis. Cancer Research. 2020 July 1. doi: 10.1158/0008-5472.CAN-19-2733. PMID: 32312834

 

• Mohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, de Mingo Pulido A, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hänggi K, Anadon CM, Flores ER, Haura EB, Mehrotra S, Pilon-Thomas S, Ruffell B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC. The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling. Immunity. 2020 April 14. doi: 10.1016/j.immuni.2020.03.004. PMID: 32294407. 

 

• Alam H, Tang M, Maitituoheti M, Dhar SS, Kumar M, Han CY, Ambati CR, Amin SB, Gu B, Chen TY, Lin YH, Chen J, Muller FL, Putluri N, Flores ER, DeMayo FJ, Baseler L, Rai K, Lee MG. KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer. Cancer Cell. 2020 April 13. doi: 10.1016/j.ccell.2020.03.005. PMID: 32243837.

 

• Davis AJ, Tsinkevich M, Rodencal J, Abbas HA, Su XH, Gi YJ, Fang B, Rajapakshe K, Coarfa C, Gunaratne PH, Koomen JM, Tsai KY, Flores ER. TAp63-regulated microRNAs suppress cutaneous squamous cell carcinoma through inhibition of a network of cell cycle genes. Cancer Research. 2020 June 15. doi: 10.1158/0008-5472.CAN-19-1892. PMID: 32156775. 

 

• Napoli M, Flores ER. Loss of p53 protein strikes a nerve to aid tumour growth. Nature. 2020 Feb. doi 10.1038/d41586-020-00328-6. PMID: 32066916

 

• Napoli M, Flores ER. The p53 family reaches the final frontier: the variegated regulation of the dark matter of the genome by the p53 family in cancer. RNA Biology. 2020 Jan 7. doi 10.1080/15476286.2019.1710054. PMID: 31910062.

 

2019 

• Kumar S, Nandi A, Mahesh A, Sinha S, Flores E, Chakrabarti R. Inducible knockout of ∆Np63 alters cell polarity and metabolism during pubertal mammary gland development. FEBS Letters. 2019 Dec 3. doi: 10.1002/1873-3468.13703. PMID: 31794060. 

 

• Napoli M, Flores ER. Beware of thy neighbor: Senescent cancer cells feast on adjacent cells to persist. Journal of Cell Biology. 2019 Nov 4. doi: 10.1083/jcb.201910040. PMID: 31628158.

 

• Trillo-Tinoco J, Sierra RA, Mohamed E, Cao Y, de Mingo-Pulido Á, Gilvary DL, Anadon CM, Costich TL, Wei S, Flores ER, Ruffell B, Conejo-Garcia JR, Rodriguez PC. AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells. Cancer Research. 2019 Oct 1. doi: 10.1158/0008-5472.CAN-19-0880. PMID: 31409640. 

 

• Gunaratne PH, Pan Y, Rao AK, Lin C, Hernandez-Herrera A, Liang K, Rait AS, Venkatanarayan A, Benham AL, Rubab F, Kim SS, Rajapakshe K, Chan CK, Mangala LS, Lopez-Berestein G, Sood AK, Rowat AC, Coarfa C, Pirollo KF, Flores ER, Chang EH. Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53-altered tumors. Cancer. 2019 Jul 15. doi: 10.1002/cncr.32053. PMID: 31012964. 

 

2018

• Jinesh GG, Flores ER, Brohl AS. Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers. PLoS One. 2018 Oct 18. doi: 10.1371/journal.pone.0206008. PMID: 30335837.

 

• Lu Y, Cao J, Napoli M, Xia Z, Zhao N, Creighton CJ, Li W, Chen X, Flores ER, McManus MT, Rosen JM. miR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution. Stem Cells. 2018 December. doi: 10.1002/stem.2914. PMID: 30267595.

 

• Dhar SS, Zhao D, Lin T, Gu B, Pal K, Wu SJ, Alam H, Lv J, Yun K, Gopalakrishnan V, Flores ER, Northcott PA, Rajaram V, Li W, Shilatifard A, Sillitoe RV, Chen K, Lee MG. MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes. Mol Cell. 2018 Jun 7. doi: 10.1016/j.molcel.2018.04.028. PMID: 29861161.

 

• Alam H, Li N, Dhar SS, Wu SJ, Lv J, Chen K, Flores ER, Baseler L, Lee MG. HP1γ Promotes Lung Adenocarcinoma by Downregulating the Transcription-Repressive Regulators NCOR2 and ZBTB7A. Cancer Research. 2018 Jul 15. doi: 10.1158/0008-5472.CAN-17-3571. PMID: 29764865.

 

• Patel V, Singh VP, Pinnamaneni JP, Sanagasetti D, Olive J, Mathison M, Cooney A, Flores ER, Crystal RG, Yang J, Rosengart TK. p63 Silencing induces reprogramming of cardiac fibroblasts into cardiomyocyte-like cells. J Thorac Cardiovasc Surg. 2018 Aug 01. doi: 10.1016/j.jtcvs.2018.03.162. PMID: 29716728.

 

• Wang C, He Y, Xu P, Yang Y, Saito K, Xia Y, Yan X, Hinton A Jr, Yan C, Ding H, Yu L, Shu G, Gupta R, Wu Q, Tong Q, Lagor WR, Flores ER, Xu Y.TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis. Nat Commun. 2018 Apr 18. doi: 10.1038/s41467-018-03796-7. PMID: 29670083.

 

• Campbell JD, Yau C, Bowlby R, Liu Y, Brennan K, Fan H, Taylor AM, Wang C, Walter V, Akbani R, Byers LA, Creighton CJ, Coarfa C, Shih J, Cherniack AD, Gevaert O, Prunello M, Shen H, Anur P, Chen J, Cheng H, Hayes DN, Bullman S, Pedamallu CS, Ojesina AI, Sadeghi S, Mungall KL, Robertson AG, Benz C, Schultz A, Kanchi RS, Gay CM, Hegde A, Diao L, Wang J, Ma W, Sumazin P, Chiu HS, Chen TW, Gunaratne P, Donehower L, Rader JS, Zuna R, Al-Ahmadie H, Lazar AJ, Flores ER, Tsai KY, Zhou JH, Rustgi AK, Drill E, Shen R, Wong CK; Cancer Genome Atlas Research Network, Stuart JM, Laird PW, Hoadley KA, Weinstein JN, Peto M, Pickering CR, Chen Z, Van Waes C. Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas. Cell Rep. 2018 Apr 3. doi: 10.1016/j.celrep.2018.03.063. PMID: 29617660.

 

• Jiang Y, Xu E, Zhang J, Chen M, Flores E, Chen X. The Rbm38-p63 feedback loop is critical for tumor suppression and longevity. Oncogene. 2018 May 3. doi: 10.1038/s41388-018-0176-5. PMID: 29520104 

 

2017

• Abbas H, Bui NH, Rajapakshe K, Wong J, Gunaratne P, Tsai KY, Coarfa C, Flores ER. Distinct TP63 isoform-driven transcriptional signatures predict tumor progression and clinical outcomes. Cancer Research. 2017 Nov 27. doi: 10.1158/0008-5472. PMID: 29180475.

 

• Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, Mien-Chie Hung MC, Marks JR, Gallick GE, Lopez-Berestein G, Flores ER, Sood AK, Huang S, Yu D, Yang L, Lin C. JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. J Clin Invest. 2017 Nov 13. doi: 1172/JCI91553 [Epub ahead of print] PMID:29130936.

 

• Martin-Lopez M, Maeso-Alonso L, Fuertes-Alvarez S, Balboa D, Rodriguez-Crtez V, Weltner J, Diez-Prieto I, Davis A, Wu Y, Otonkoski T, Flores ER, Menendez P, Marques MM, Marin MC. p73 is required for appropriate BMP-induced mesenchymal-to-epithelial transition during somatic cell reprogramming. Cell Death. 2017 Sep 07. doi: 1038/cddis.2017.432. PMID: 28880267.

 

• Napoli M, Flores ER. Another case for diet restriction: TAp73-expressing medulloblastomas are stunted by glutamine withdrawal. Genes & Development. 2017 Sep 01. doi: 31(17):1715-1716. PMID: 28982757

 

• Liao W, Liu H, Zhang Y, Jung JH, Chen J, Su X, Kim YC, Flores ER, Wang SM, Czarny-Ratajczak M, Li W, Zeng SX, Lu H. Ccdc3: A New P63 Target Involved in Regulation Of Liver Lipid Metabolism. Scientific Reports. 2017 Aug 21. doi: 10.1038/s41598-017-09228-8. PMID: 28827783.

 

• Rigoutsos I, Lee SK, Nam SY, Anfossi S, Pasculli B, Pichler M, Jing Y, Rodriguez-Aguayo C, Telonis AG, Rossi S, Ivan C, Catela Ivkovic T, Fabric L, Clark PM, Ling H, Shimizu M, Redis RS, Shah MY, Zhang X, Okugawa Y, Jung EJ, Tsirigos A, Huang L, Ferdin J, Gafa R, Spizzo R, Nicoloso MS, Paranjape AN, Shariati M, Tiron A, Yeh JJ, Teruel-Montoya R, Xiao L, Melo SA, Menter D, Jiang ZQ, Flores ER, Negrini M, Goel A, Bar-Eli M, Mani SA, Liu CG, Lopez-Berestein G, Berindan-Neagoe I, Esteller M, Kopetz S, Lanza G, Calin GA. N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration. Genome Biol. 2017 May 24. doi: 10.1186/s13059-017-1224-0. PMID: 28535802.

 

• Napoli M, Flores ER. The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy. British Journal of Cancer. 2017 Jan 17. doi: 116(2): 149-155. PMID: 27884017.

 

2016

• Flores ER. Commentary on "Apoptosis, p53, and Tumor Cell Sensitivity to Anticancer Agents". Cancer Research. 2016 Dec 01. doi: 10.1158/0008-5472.CAN-16-2997. PMID: 27909063

 

• Su X, Napoli M, Abbas HA, Venkatanarayan A, Bui NH, Coarfa C, Gi YJ, Kittrell F, Gunaratne PH, Medina D, Rosen JM, Behbod F, Flores ER. TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway. Oncogene. 2016 Nov 21. doi: 10.1038/onc.2016.388. PMID:27869165.

 

• Matre P, Velez J, Jacamo R, Qi Y, Su X, Cai T, Chan SM, Lodi A, Sweeney SR, Ma H, Davis RE, Baran N, Haferlach T, Su X, Flores ER, Gonzalez D, Konoplev S, Samudio I, DiNardo C, Majeti R, Schimmer AD, Li W, Wang T, Tiziani S, Konopleva M. Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes. Oncotarget. 2016 Oct 27. doi: 10.18632/oncotarget.12944. PMID: 27806325.

 

• Chitsazzadeh V, Coarfa C, Drummond JA, Nguyen T, Joseph A, Chilukuri S, Charpiot E, Adelmann CH, Ching G, Nguyen TN, Nicholas C, Thomas VD, Migden M, MacFarlane D, Thompson E, Shen J, Takata Y, McNiece K, Polansky MA, Abbas HA, Rajapakshe K, Gower A, Spira A, Covington KR, Xiao W, Gunaratne P, Pickering C, Frederick M, Myers JN, Shen L, Yao H, Su X, Rapini RP, Wheeler DA, Hawk ET, Flores ER, Tsai KY. Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates. Nat Commun. 2016 Aug 30. doi: 10.1038/ncomms12601. PMID: 27574101.

 

• Adelmann CH, Truong KA, Liang RJ, Bansal V, Gandee L, Saporito RC, Lee W, Du L, Nicholas C, Napoli M, Mino B, South AP, Proby CM, Leigh IM, Coarfa C, Flores ER, Tsai KY. MEK is a therapeutic chemopreventive target in squamous cell carcinoma. J Invest Dermatol. 2016 Sep13. doi: 10.1016/j.jid.2016.05.110. Epub 2016 Jun 9. PMID: 27293029.

 

• Napoli M, Flores ER. Unifying the p73 knockout phenotypes: TAp73 orchestrates multiciliogenesis. Genes & Development. 2016 June 01. doi: 30(11):1253-1254. PMID: 27298333. 

 

• Wang Y, Wang X, Flores ER, Yu J, Chang S. Dysfunctional telomeres induce p53- dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation. Aging Cell. 2016 April 26. doi: 10.1111/acel.12476. PMID: 27113195.

  

• Wu Y, Lindblad JL, Garnett J, Kamber Kaya HE, Xu D, Zhao Y, Flores ER, Hardy J, Bergmann A. Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila. Cell Death Differ. 2016 Apr 23. doi: 10.1038/ccd.2015.144. PMID: 26542461

 

• Napoli M, Venkatanarayan A, Raulji P, Meyers BA, Norton W, Mangala LS, Sood AK, Rodriguez-Aguayo C, Lopez-Berestein G, Vin H, Duvic M, Tetzlaff MB, Curry JL, Rook AH, Abbas HA, Coarfa C, Gunaratne PH, Tsai KY, Flores ER. ∆Np63/DGCR8- Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer. Cancer Cell. 2016 Jun 13. doi: 10.1016/j.ccell.2016.04.016. PMID: 27300436. (*Featured in Science Signaling. http://stke.sciencemag.org/content/9/435/ec155)

           

 

2015

• Venkatanarayan A, Raulji P, Norton W, Flores ER. Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73. Cell Cycle. 2015 Dec 10. doi: 10.1080/15384101.2015.1121333. PMID: 26652033.

 

• Singh MM, Johnson B, Venkatarayan A, Flores ER, Zhang J, Su X, Barton M, Lang F, Chandra J. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro Oncol. 2015 Nov 17. doi: 10.1093/neuonc/nov041. PMID: 25795306.

 

2014

• Venkatanarayan A, Raulji P, Norton W, Chakravarti D, Coarfa C, Su X, Sandur SK, Ramirez MS, Lee J, Kingsley CV, Sananikone EF, Rajapakshe K, Naff K, Parker-Thornburg J, Bankson JA, Tsai KY, Gunaratne PH, Flores ER. IAPP driven metabolic reprogramming induces regression of p53 - deficient tumours in vivo. Nature. 2014 Nov 17. doi: 10.1038/nature13910. PMID: 25409149. (*Featured in Nature Reviews Cancer. http://www.nature.com/articles/nrc3881 and Cancer Discovery. http://cancerdiscovery.aacrjournals.org/content/early/2014/12/02/2159-8290.CD-RW2014-248.full)

           

 

• Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han HD, Zhang D, Venkatanarayan A, Krohn M, Kristensen VN, Gagea M, Ram P, Liu W, Lopez- Berestein G, Lorenzi PL, Børresen-Dale AL, Chin K, Gray J, Dusetti NJ, McGuire SE, Flores ER, Sood AK, Mills GB. Copy number gain of hsa-miR-569 at 3q26.2 Leads to Loss of TP53INP1 and Aggressiveness of Epithelial Cancers. Cancer Cell. 2014 Dec 8. doi: 10.1016/j.ccell.2014.10.010. PMID: 25490449.  

 

•  Chakravarti D, Su X, Cho MS, Bui NH, Coarfa C, Venkatanarayan A, Benham AL, Flores González RE, Alana J, Xiao W, Leung ML, Vin H, Chan IL, Aquino A, Müller N, Wang H, Cooney AJ, Parker-Thornburg J, Tsai KY, Gunaratne PH, Flores ER. Induced multipotency in adult keratinocytes through down-regulation of ∆Np63 or DGCR8. Proc Natl Acad Sci U S A. 2014 Feb 04. doi: 10.1073/pnas.1319743111. PMID: 24449888.

 

2013

• Vin H, Ojeda SS, Ching G, Leung ML, Chitsazzadeh V, Dwyer DW, Adelmann CH, Restrepo M, Richards KN, Stewart LR, Du L, Ferguson SB, Chakravarti D, Ehrenreiter K, Baccarini M, Ruggieri R, Curry JL, Kim KB, Ciurea AM, Duvic M, Prieto VG, Ullrich SE, Dalby KN, Flores ER, Tsai KY. BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.  Elife. 2013 Nov 05. doi: 10.7554/eLife.00969. PMID: 24192036. 

 

• Cancino GI, Yiu AP, Fatt MP, Dugani CB, Flores ER, Frankland PW, Josselyn SA, Miller FD, Kaplan DR. p63 regulates adult neural precursor and newly-born neuron survival to control hippocampal-dependent behavior. J Neurosci.  2013 Jul 31. doi: 10.1523/JNEUROSCI.1251-13.2013. PMID: 23904595.

 

• Tan EH, Morton JP, Timpson P, Tucci P, Melino G, Flores ER, Sansom OJ, Vousden KH, Muller PA. Functions of TAp63 and p53 in restraining the development of metastatic cancer. Oncogene. 2014 Jun 19. doi: 10.1038/onc.2013.287. PMID: 23873029. 

 

• Eno CO, Zhao G, Venkatanarayan A, Wang B, Flores ER, Li C. Noxa couples lysosomal membrane permeabilization and apoptosis during oxidative stress. Free Radic Biol. 2013 Jun 14. doi: 10.1016/j.freeradbiomed.2013.05.051. PMID: 23770082.

 

• Chari NS, Romano RA, Koster MI, Jaks V, Roop D, Flores ER, Teglund S, Sinha S, Gruber W, Aberger F, Medeiros LJ, Toftgard R, McDonnell TJ. Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis. Cell Death Differ. 2013 May 17. doi: 10.1038/cdd.2013.41. PMID: 23686138. 

 

• Terrinoni A, Serra V, Bruno E, Strasser A, Valente E, Flores ER, van Bokhoven H, Lu X, Knight RA, Melino G. Role of p63 and the Notch pathway in cochlea development and sensorineural deafness. Proc Natl Acad Sci USA. 2013 Apr 15. doi: 10.1073/pnas.1214498110. PMID: 23589895. 

 

• Liao JM, Zhang Y, Liao W, Zeng SX, Su X, Flores ER, Lu H. IκB Kinase β (IKKβ) inhibits p63 isoform γ (TAp63γ) transcriptional activity. J Biol Chem. 2013 Apr 15. doi: 10.1074/jbc.M113.466540. PMID: 23589370. 

 

2012

• Tran MN, Choi W, Wszolek MF, Navai N, Lee IL, Nitti G, Wen S, Flores ER, Siefker- Radtke A, Czerniak B, Dinney C, Barton M, McConkey DJ. The p63 isoform ∆Np63α inhibits epithelial-mesenchymal transition in human bladder cancer cells: Role of miR205. J Biol Chem. 2012 Dec 13. doi: 10.1074/jbc.M112.408104. PMID: 23239884. 

 

• Su X, Gi YJ, Chakravarti D, Chan IL, Zhang A, Xia X, Tsai KY, Flores ER. TAp63 is a Master transcriptional Regulator of Lipid and Glucose Metabolism. Cell Metab. 2012 Oct 03. doi: 10.1016/j.cmet.2012.09.006. PMID: 23040072. (*Featured in  Nature Reviews Cancer. http://www.nature.com/articles/nrc3386)

          

 

• Ahn YH, Gibbons DL, Chakravarti D, Creighton CJ, Rizvi ZH, Adams HP, Pertsemlidis A, Gregory PA, Wright JA, Goodall GJ, Flores ER, Kurie JM. ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. J Clin Invest. 2012 Aug 01. doi: 10.1172/JCI63608. PMID: 22850877. PMCID: PMC3428095. 

 

• Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moore KA, Snoeck HW, Ma'ayan A, Schaniel C, Lemischka IR. Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling. Cell Stem Cell. 2012 Aug 03. doi: 10.1016/j.stem.2012.05.020. PMID: 22862944. 

 

2011

• Wu H, Zeinab RA, Flores ER, Leng RP. Pirh2, a Ubiquitin E3 Ligase, Inhibits p73 Transcriptional Activity by Promoting its Ubiquitination. Mol Cancer Res. 2011 Oct 12. doi: 10.1158/1541-7786.MCR-11-0157. PMID: 21994467.

 

• Mitani Y, Li J, Weber RS, Lippman SL, Flores ER, Caulin C, El-Naggar AK. Expression and regulation of the ∆N and TAp63 isoforms in salivary gland tumorigenesis clinical and experimental findings. Am J Pathol. 2011 May 07. doi: 10.1016/j.ajpath.2011.03.037. PMID: 21703418.

 

• Bornstein C, Brosh R, Molchadsky A, Madar S, Kogan-Sakin I, Goldstein I, Chakravarti D, Flores ER, Goldfinger N, Sarig R, Rotter V. SPATA18, a Spermatogenesis- Associated Gene, Is a Novel Transcriptional Target of p53 and p63. Mol Cell Biol. 32011 Feb 07. doi: 10.1128/MCB.01072-10. PMID: 21300779. 

 

2010

• Su X, Chakravarti D, Cho MS, Liu L, Gi YJ, Lin YL, Leung ML, El-Naggar A, Creighton CJ, Suraokar MB, Wistuba I, Flores ER. TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature. 2010 Oct 20. doi: 10.1038/nature09459. PMID: 20962848. (*Featured in Science. http://science.sciencemag.org/content/331/6024/1551.full ; Nature Reviews Cancer. http://www.nature.com/articles/nrc2978 and Genome Biology. https://genomebiology.biomedcentral.com/articles/10.1186/gb-2010-11-11-141)

           

 

• Cho MS, Chan IL, Flores ER. DeltaNp63 transcriptionally regulates brachyury, a gene with diverse roles in limb development, tumorigenesis and metastasis. Cell Cycle. (2010 Jun 15. doi: 10.4161/cc.9.12.12051. PMID: 20519941. (*Featured in Cell Cycle. https://www.tandfonline.com/doi/pdf/10.4161/cc.9.13.12238)

          

 

2009

• Lin Y-L, Sengupta S, Gurdziel K, Bell, G, Jacks T, and Flores ER. p63 and p73 transcriptionally regulate genes involved in DNA repair. PLoS Genetic. 2009 Oct 5. doi: 10.1371/journal.pgen.1000680. PMID: 19816568.  

 

• Su X, Paris M, Gi Y-J, Tsai KY, Cho MS, Lin Y-L, Biernaskie JA, Sinha S, Prives C, Pevny LH, Miller FD, and Flores ER. TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell. 2009 Jul 02. doi: 10.1016/j.stem.2009.04.003. PMId: 19570515. (*Featured in Cell Stem Cell. http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(09)00294-X

           

• Su X, Cho MS, Gi YJ, Ayanga BA, Sherr CJ, Flores ER. Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf. EMBO J. 2009 Jun 04. doi: 10.1038/emboj.2009.151. PMID: 19494829.  

 

1997 - 2007

• Talos F, Nemajerova A, Flores ER, Petrenko O, and Moll U. p73 suppresses polyploidy and aneuploidy in the absence of functional p53. Mol Cell. 2007 Aug 17. doi: 10.1016/j.molcel.2007.06.036. PMID: 17707235.

 

• Flores ER, Sengupta S, Miller JB, Newman JJ, Bronson R, Crowley D, Yang A, McKeon F, Jacks T. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell. 2005 Apr 18. doi: 10.1016/j.ccr.2005.02.019. PMID: 15837625. 

 

•  Reczek EE, Flores ER, Tsay AS, Attardi LD, Jacks T. Multiple response elements and differential p53 binding control Perp expression during apoptosis. Mol Cancer Res. 2004 Jan 05. PMID: 14707288.

 

• Flores ER, Tsai KY, Crowley D, Sengupta S, Yang A, McKeon F, Jacks T. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature. 2002 Apr 04. doi: 10.1038/416560a. PMID: 11932750. (*Featured in Cancer Cell. http://www.cell.com/cancer-cell/fulltext/S1535-6108(02)00064-8 and Nature Reviews Cancer. http://www.nature.com/articles/nrc804)  

              

 

• de Vries A, Flores ER, Miranda B, Hsieh HM, van Oostrom CT, Sage J, Jacks T. Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function. Proc Natl Acad Sci USA. 2002 Feb 26. doi: 10.1073/pnas.052713099. PMID: 11867759.

 

• Duensing S, Duensing A, Flores ER, Do A, Lambert PF, Munger K. Centrosome abnormalities and genomic instability by episomal expression of human papillomavirus type 16 in raft cultures of human keratinocytes. J Virol. 2001 Aug. doi: 10.1128/JVI.75.16.7712-7716.2001. PMID: 11462043.

 

• Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W, Flores ER, Tsai KY, Jacks T, Vousden KH, Kaelin WG, Jr. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature. 2000 Oct 05. doi: 10.1038/35036614. PMID: 11034215.

 

• Flores ER, Allen-Hoffmann BL, Lee D, Lambert PF. The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle. J Virol. 2000 Jul. doi: 10.1128/JVI.74.14.6622-6631.2000. PMID: 10864676. 

 

• Flores ER, Allen-Hoffmann BL, Lee D, Sattler CA, Lambert PF. Establishment of the human papillomavirus type 16 (HPV-16) life cycle in an immortalized human foreskin keratinocyte cell line. Virology. 1999 Sep 30. doi: 10.1006/viro.1999.9868. PMID: 10502513.  

 

• Flores ER, Lambert PF. Evidence for a switch in the mode of human papillomavirus type 16 DNA replication during the viral life cycle. J Virol. 1997 Oct. PMID: 9311789.