Suman Govindaraju, Michelle Maurin, Justin Y. Newberg, Devin J. Jones, Hubert Lee, Judit E. Markovitz, Michael B. Mann, Michael A. Black, and Karen M. Mann. Insertional mutagenesis defines drivers and evolutionary relationships in pancreatic cancer metastasis. bioRxiv 2020.09.28.317701; bioRūĚõėiv.¬†doi:¬†https://doi.org/10.1101/2020.09.28.317701.¬†Data: 1 | 2¬†

Aziz Aiderus,¬†Ana M. Contreras-Sandoval, Amanda L. Meshey,¬†Justin Y. Newberg,¬†Jerrold M. Ward, Deborah Swing,¬†Neal G. Copeland, Nancy A. Jenkins, Karen M. Mann, and¬†Michael B. Mann. Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation.¬†bioRūĚõėiv.¬†doi:¬†10.1101/2020.08.17.254565.¬†¬†Data: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10¬†


Elnara Muradova, Nishit Patel, Brittney Sell, Bruna B. Bittencourt, Sandra S. Ojeda, Charles H. Adelmann, Ling Cen, Chia-Ho Cheng, Jianjun Shen, Christel M. Davis, Erik A. Ehli, Justin Y. Newberg, Basil Cherpelis, Michael A. Black, Michael B. Mann, Samir Mitragotri, and Kenneth Y. Tsai. Non-invasive assessment of epidermal genomic markers of UV exposure in skin. Journal of Investigative Dermatology. In Press, Journal Pre-proof available online 15 June 2020. doi:10.1016/j.jid.2020.05.093. 



Aziz Aiderus, Justin Y. Newberg, Liliana Guzman-Rojas, Ana M. Contreras-Sandoval, Amanda L. Meshey, Devin J. Jones, Felipe Amaya-Manzanares, Roberto Rangel, Jerrold M. Ward, Song-Choon Lee, Kenneth Hon-Kim Ban, Keith Rogers, Susan M. Rogers, Luxmanan Selvanesan, Leslie A. McNoe, Neal G. Copeland, Nancy A. Jenkins, Kenneth Y. Tsai, Michael A. Black, Karen M. Mann, and¬†Michael B. Mann. Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression.¬†bioRūĚõėiv.¬†doi: https://doi.org/10.1101/2019.12.24.887968. Open Access¬†Manuscript:¬†PDF-v1 ¬†Data: 1¬†| 2 | 3¬†| 4¬†



Newberg JY, Black MA, Jenkins NA, Copeland NG, Mann KM, and Mann MB. SB Driver Analysis: A Sleeping Beauty cancer driver analysis framework for identifying and prioritizing experimentally actionable oncogenes and tumor suppressors. Nucleic Acids Research. 2018 Sep 19;46(16):e94. Published online before print May 26, 2018. doi:10.1093/nar/gky450. PMID: 29846651; PMCID: PMC6144815. Open Access Manuscript: PDF 

Newberg JY, Mann KM, Mann MB, Jenkins NA, and Copeland NG. SBCDDB: Sleeping Beauty Cancer Driver Database for gene discovery in mouse models of human cancers. Nucleic Acids Research. 2018 Jan 4;46(D1):D1011-D1017. Published online before print October 20, 2017. doi:10.1093/nar/gkx956. PMID: 29059366; PMCID: PMC5753260. Open Access Manuscript: PDF. Published in The 2018 Nucleic Acids Research database issue and the online molecular biology database collection. 

Available at http://sbcddb.moffitt.org/.



Mann KM, Newberg JY, Black MA, Jones DJ, Amaya-Manzanares F, Guzman-Rojas L, Kodama T, Ward J, Rust AG, van der Weyden L, Chin KY, Waters J, Leung ML, Rogers K, Rogers SM, McNoe L, Selvanesan L, Navin N, Jenkins NA, Copeland NG, and Mann MB. Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells using SBCapSeq. Nature Biotechnology. 2016, 34(9):962‚Äď972. Published online before print August 1, 2016 doi:10.1038/nbt.3637. PMID:¬†27479497; PMCID:¬†PMC6124494.¬†Press: 1|2|3 | Data: 1|2|3|4 | Analysis: 1|2|3.¬†Open Access¬†Manuscript: PMC PDF.


Mann KM, Guzman-Rojas L, Amaya-Manzanares F, Jones DJ, Newberg JY, Jenkins NA, Copeland NG, and Mann MB*. SBCapSeq Protocol: a method for selective cloning of Sleeping Beauty transposon insertions using liquid capture hybridization and Ion Torrent semiconductor sequencing. Protocol Exchange. 2016. doi:10.1038/protex.2016.053. Open Access Manuscript: PDF-v1. Published online August 3, 2016 at Protocol Exchange. *corresponding author

Rangel R, Lee SC, Ban K, Mann MB, Newberg JY, Guzman-Rojas L, Kodama T, McNoe LA, Selvanesan L, Ward JM, Rust AG, Chin KY, Black MA, Jenkins NA, and Copeland NG. Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression. Proc Natl Acad Sci U S A. 2016. pii: 201613859. Published online before print November 14, 2016. doi:10.1073/pnas.1613859113. PMID: 27849608; PMCID: PMC5137755. 



Mann MB, Black MA, Jones DJ, Ward J, Chin KY, Newberg JY, Dupuy AJ, Rust AG, Bosenberg MW, McMahon M, Print CG, Copeland NG, and Jenkins NA. Transposon mutagenesis identifies genetic drivers of BrafV600E melanoma. Nature Genetics. 2015, 47(5):486‚Äď495. Published online before print April 13, 2015 doi:10.1038/ng.3275. PMID:¬†25848750; PMCID:¬†PMC4844184.¬†Press: 1|2|3|4|5 | Data: 1.¬†Open Access¬†Manuscript: PMC PDF

View high resolution Houston Methodist press.

Goh AM, Xue Y, Leushacke M, Li L, Wong JS, Chiam PC, Rahmat SA,¬†Mann MB, Mann KM, Barker N, Lozano G, Terzian T, and Lane DP. Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice.¬†Oncotarget. 2015, 6(20):17968‚Äď17980. Published online July 22, 2015 at¬†http://www.impactjournals.com/oncotarget/.

Takeda H, Wei Z, Koso H, Rust AG, Chin KY,¬†Mann MB, Ward JM, Adams DJ, Copeland NG, and Jenkins NA. Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.¬†Nature Genetics. 2015. 47(2):142‚Äď150. Published online before print January 5, 2015.¬†doi:10.1038/ng.3175.¬†PMID:¬†25559195.¬†



Mann MB, Jenkins NA, Copeland NG, and Mann KM. Sleeping Beauty mutagenesis: exploiting forward genetic screens for cancer gene discovery. Curr. Opin. Genet. Dev.. 2014, Published online before print December 20, 2013, Volume 24C: 16‚Äď22. doi:10.1016/j.gde.2013.11.004.¬†PMID:¬†24657532..¬†



Mann KM, Jenkins NA, Copeland NG, and Mann MB. Transposon Insertional Mutagenesis Models of Cancer. Cold Spring Harb Protoc. 2014 Mar 1; 2014(3):235‚Äď247. pii:pdb.top069849. doi: 10.1101/pdb.top069849. PubMed PMID: 24591685. Also appears in Mouse Models of Cancer: A Laboratory Manual; pages 173‚ÄĒ185; Edited by Abate-Shen C, Politi K, Olive K, and Chodosh L. Oxford University Press. November 30, 2013. doi:10.1101/pdb.top069849. CSHL Press | Amazon | Barnes & Noble.

Trevarton AJ, Mann MB, Knapp C, Araki H, Wren JD, Stones-Havas S, Black MA, and Print CG. MelanomaDB: a web tool for integrative analysis of melanoma genomic information to identify disease-associated molecular pathways. Front. Oncol. 2013, 3:184. doi: 10.3389/fonc.2013.00184.  PMID: 23875173; PMCID: PMC3712543. 

Learn more at https://apps.biomatters.com/.



Goh AM, Lim CY, Chiam PC, Li L,¬†Mann MB, Mann KM, Menendez S, and Lane DP. Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity.¬†PNAS USA.¬†2012, Published online before print January 17, 2012, 109(5):1685‚Äď1690.¬†doi: 10.1073/pnas.1114173109.¬†PMID:¬†22307631; PMCID:¬†PMC3277193.¬†