Kiran Mahajan Lab




  1. Mahajan NP*, Coppola D, Kim J, Lawrence H, Lawrence N and Mahajan K*, Blockade of ACK1/TNK2 signaling to squelch survival of Prostate Cancer Stem-like Cells. (*co-corresponding author)  Scientific Reports, 2018.


  1. Mahajan K, Malla P, Lawrence HR, Chen Z, Kumar-Sinha C, Malik R, Shukla S, Kim J, Coppola D, Lawrence NJ, Mahajan NP.   Cancer Cell 2017 Jun 12;31(6):790-803. PUB med 28609657
  2. Mahajan N*, Pavani Malla, Amod Sarnaik, Jongphil Kim, Shari Pillon-Thomas, Jeffery Weber, and Mahajan K*. WEE1 epigenetically modulates 5-hmC levels by pY37-H2B dependent regulation of IDH2 gene expression (Oncotarget, 2017).


  1. A N Paranjape, R Soundararajan, S J Werden, R Joseph, J H Taube, H Liu, J Rodriguez-Canales, N Sphyris, I Wistuba, N Miura, J Dhillon, N Mahajan, K Mahajan, J T Chang, M Ittmann, S N Maity, C Logothetis, D G Tang and S A Mani Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties Oncogene 2016 35, 5963–5976
  2. Mahajan K* hPso4/hPrp19: A Critical Component of DNA Repair and DNA Damage Checkpoint Complexes Oncogene, 2016. 35, 2279-2286


  1. Mahajan K* and Mahajan NP. Cross talk of Tyrosine Kinases with the DNA Damage Signaling Pathways Nucleic Acids Research, 2015; 43(22):10588-601.
  2. Lawrence HR, Mahajan K, Liu Y, Zhang D, Tindal N, Huseyin M, Gevariya H, Kazi S, Ozcan S, Mahajan NP*, Lawrence NJ*. Development of novel ACK1 inhibitors using a fragment based approach. J Med Chem. 2015 58(6):2746-2763.


  1. Mahajan K*, Lawrence H, Lawrence NJ and Mahajan NP*. ACK1 Tyrosine Kinase Interacts with KDM3A to Regulate the Mammary Tumor Oncogene HOXA1. J Biol Chem, 289:28179-91, 2014.
  2. Mahajan K* and Mahajan NP*. ACK1/TNK2 tyrosine kinase: Molecular signaling and evolving role in cancer. Oncogene, 2014. 34(32):4162-7
  3. Mahajan K* and Mahajan NP*. AKT goes Cycling. Cancer Control, 21:239-4, 2014.


  1. Mahajan K* and Mahajan NP*. Epigenetic Regulation of Core Histone Transcription: WEE1 as a Novel Epigenetic Modifier. Trends in Genetics, 29:394-402, 2013.
  2. Mahajan K* and Mahajan NP*. Ack1 tyrosine kinase as an anticancer target in human cancer. Cancer Letters, 338:185-92, 2013.


  1. Mahajan K, Fang B, Koomen J and Mahajan NP. H2B tyrosine 37-phosphorylation regulates expression of histone genes. Nature Structural & Molecular Biology, 19:930-937, 2012.Highlighted by Nature on their website,   Article of the month    Faculty of 1000 selected article 
  2.  Mahajan K, Coppola D, Rawal B, Chen A, Lawrence H, Engelman RW, Lawrence NJ and Mahajan NP. Ack1/TNK2 inhibitor suppresses growth of Radioresistant Castration-Resistant Prostate Cancer. J Biol Chem, 287:22112-22, 2012.  Highlighted in the SciBX, a translational science weekly from Nature Publishing Group in May 24th, 2012 issue.  Highlighted in Prostate Cell News, a weekly newsletter from Connexon Creative Inc.
  3.  Mahajan K* and Mahajan NP. PI3K-independent AKT activation in cancers: A treasure trove for novel therapeutics. Journal of Cellular Physiology, 227:3178-84, 2012
  4.  Mahajan K, Coppola D, Lawrence H, Luo Y, Zhu W, Chen A, Lawrence NJ and Mahajan NP. Ack1 Tyrosine Kinase Activation Correlates with Pancreatic Cancer Progression. American Journal of Pathology, 180:1386-93, 2012.


  1. Mahajan K and Mahajan NP Shepherding AKT and Androgen Receptor by Ack1 tyrosine kinase. J Cell Physiology, 224:327-33, 2010.
  2. Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, Lopez AS, Koomen J, Engelman RW, Rivera C, Muraoka-Cook RS, Cheng JQ, Schönbrunn E, Sebti SM, Earp HS, Mahajan NP. Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation. PLoS One.5(3):e9646, 2010.
  3. Mahajan K, Challa S, Coppola D, Lawrence H, Luo Y, Gevariya H, Zhu W, Chen YA, Lawrence NJ, Mahajan NP. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. The Prostate, 2010.



  1. Anuradha S., Tripathi P., Mahajan, K., Muniyappa, K. Meiosis-specific yeast Hop1 protein promotes pairing of double-stranded DNA helices via G/C isochores. Biochemical and Biophysical Research Communications, 28;336(3):934-41, 2005.
  2. Mahajan, K* and Mitchell, B.S. Role of human Pso4 in Mammalian DNA Repair and Association with Terminal Deoxynucleotidyl Transferase. Proc. Natl. Acad. Sci. USA. 100:10746-10751, 2003.
  3. Mahajan, K, McElhinny, S,A,N., Mitchell, B. S., and Ramsden, D.A. Association of DNA Polymerase µ (pol µ) with Ku and Ligase IV: Role for pol µ in End-Joining Double-Strand Break Repair. Molecular and Cellular Biology, 22:5194-5202, 2002.
  4. Mahajan, K, Gangi-Peterson, L., Sorscher, D.H., Wang, J, Gathy, K.N., Mahajan, N.P., Reeves, W.H., and Mitchell, B.S. Association of Terminal deoxynucleotidyl transferase with Ku Proc. Natl. Acad. Sci. USA. 96:13926-13931, 1999.