ACK1 Activation in Prostate Cancer
Activated ACK1 (pTyr284-ACK1) expression correlates positively with disease progression and negatively with survival of prostate cancer patients. Figure on right shows: (A) TMA sections representing different prostate cancer stages were stained with pTyr284-ACK1antibodies. (B) Increasing expression of pTyr284-ACK1 in later stages of prostate cancer. (C) Kaplan-Meier survival curves shows that individuals with prostate cancer that have moderate to strong staining of pTyr284-ACK1(>2 )have a significantly worse overall survival outcome than those with lower pTyr284-ACK1 levels.
ACK1-AKT signaling in Triple Negative Breast Cancer (TNBC)