Hifzur Siddique, PhD

Postdoctoral Research Associate

Research Interests:

Prostate cancer, Long non-coding RNAs, Stem Cells


Selected Publications:

NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer. Siddique HR, Feldman DE, Chen CL, Punj V, Tokumitsu H, Machida K. Hepatology. 2015 Nov;62(5):1466-79. doi: 10.1002/hep.27987. Epub 2015 Aug 28.

ROBO1, a tumor suppressor and critical molecular barrier for localized tumor cells to acquire invasive phenotype: study in African-American and Caucasian prostate cancer models. Parray A, Siddique HR, Kuriger JK, Mishra SK, Rhim JS, Nelson HH, Aburatani H, Konety BR, Koochekpour S, Saleem M. Int J Cancer. 2014 Dec 1;135(11):2493-506. doi: 10.1002/ijc.28919. Epub 2014 Apr 29.

Differential effects of genistein on prostate cancer cells depend on mutational status of the androgen receptor. Mahmoud AM, Zhu T, Parray A, Siddique HR, Yang W, Saleem M, Bosland MC. PLoS One. 2013 Oct 22;8(10):e78479. doi: 10.1371/journal.pone.0078479. eCollection 2013.

The S100A4 Oncoprotein Promotes Prostate Tumorigenesis in a Transgenic Mouse Model: Regulating NFκB through the RAGE Receptor. Siddique HR, Adhami VM, Parray A, Johnson JJ, Siddiqui IA, Shekhani MT, Murtaza I, Ambartsumian N, Konety BR, Mukhtar H, Saleem M. Genes Cancer. 2013 May;4(5-6):224-34. doi: 10.1177/1947601913492420.

BMI1 polycomb group protein acts as a master switch for growth and death of tumor cells: regulates TCF4-transcriptional factor-induced BCL2 signaling. Siddique HR, Parray A, Tarapore RS, Wang L, Mukhtar H, Karnes RJ, Deng Y, Konety BR, Saleem M. PLoS One. 2013 May 6;8(5):e60664. doi: 10.1371/journal.pone.0060664. Print 2013.

BMI1, stem cell factor acting as novel serum-biomarker for Caucasian and African-American prostate cancer. Siddique HR, Parray A, Zhong W, Karnes RJ, Bergstralh EJ, Koochekpour S, Rhim JS, Konety BR, Saleem M. PLoS One. 2013;8(1):e52993. doi: 10.1371/journal.pone.0052993. Epub 2013 Jan 7. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/d612ee51-4c8e-4468-8373-3d4c503f0da5.

Androgen receptor in human health: a potential therapeutic target. Siddique HR, Nanda S, Parray A, Saleem M. Curr Drug Targets. 2012 Dec;13(14):1907-16. Review.

Castration-resistant prostate cancer: potential targets and therapies. Parray A, Siddique HR, Nanda S, Konety BR, Saleem M. Biologics. 2012;6:267-76. doi: 10.2147/BTT.S23954. Epub 2012 Aug 17.

Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: preclinical and clinical evidences. Siddique HR, Saleem M. Stem Cells. 2012 Mar;30(3):372-8. doi: 10.1002/stem.1035. Review.

Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model. Siddique HR, Liao DJ, Mishra SK, Schuster T, Wang L, Matter B, Campbell PM, Villalta P, Nanda S, Deng Y, Saleem M. Int J Cancer. 2012 Oct 1;131(7):1720-31. doi: 10.1002/ijc.27409. Epub 2012 Feb 18.

S100A4 calcium-binding protein is key player in tumor progression and metastasis: preclinical and clinical evidence. Mishra SK, Siddique HR, Saleem M. Cancer Metastasis Rev. 2012 Jun;31(1-2):163-72. doi: 10.1007/s10555-011-9338-4. Review.

 

Hifzur Siddique

B.Sc., Assam University

Ph.D., Indian Institute of Toxicological Research

Contact:
SRB-4, Lab # 24234
Moffitt Cancer Center
12902 Magnolia Drive
Tampa, Florida 33612

Email:
hifzur.siddique@moffitt.org

Phone:
Lab: 813-745-6025