Publications

(for a fully updated list, visit PubMed)

Lim JS, Ibaseta A, Fischer MM, Cancilla B, O’Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu Y-W, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J. Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer. Nature. 2017 May 18;545(7654):360–364.

 

Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ. Non-equivalence of Wnt and R-spondin ligands during Lgr5(+) intestinal stem-cell self-renewal. Nature. 2017 May 3; PMID: 28467820

Luca VC, Kim BC, Ge C, Kakuda S, Wu D, Roein-Peikar M, Haltiwanger RS, Zhu C, Ha T, Garcia KC. Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science. 2017 Mar 2;eaaf9739. PMID: 28254785

Zuiani A, Chen K, Schwarz MC, White JP, Luca VC, Fremont DH, Wang D, Evans MJ, Diamond MS. A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I. J Virol. 2016 Dec 1;90(23):10499–10512. PMCID: PMC5110168

Spangler JB, Tomala J, Luca VC, Jude KM, Dong S, Ring AM, Votavova P, Pepper M, Kovar M, Garcia KC. Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity. 2015 May 19;42(5):815–825. PMCID: PMC4439582

Luca VC, Jude KM, Pierce NW, Nachury MV, Fischer S, Garcia KC. Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science. 2015 Feb 20;347(6224):847–853. PMID: 25700513

Luca VC, Nelson CA, Fremont DH. Structure of the St. Louis encephalitis virus postfusion envelope trimer. J Virol. 2012 Oct 31; PMID: 23115296

Luca VC, AbiMansour J, Nelson CA, Fremont DH. Crystal Structure of the Japanese Encephalitis Virus Envelope Protein. Spotlight Article. J Virol. 2012 Feb 15;86(4):2337–2346.

Sabo MC, Luca VC, Ray SC, Bukh J, Fremont DH, Diamond MS. Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperature. Virology. 2012 Jan 20;422(2):174–184. PMID: 22078164

Sabo MC, Luca VC, Prentoe J, Hopcraft SE, Blight KJ, Yi M, Lemon SM, Ball JK, Bukh J, Evans MJ, Fremont DH, Diamond MS. Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step. J Virol. 2011 Jul;85(14):7005–7019. PMID: 21543495

 


Reviews & Media

Blacklow SC. News and Views: Notch catches a Jagged edge. Nat Chem Biol. 2017 May 17;(13):570–571.

Ray BL. This Week in Science: Tugging on Notch receptor tunes signaling. Science. 2017 Mar 24;355(6331):1277.

Strzyz P. Cell signalling: Notch under tension. Nat Rev Mol Cell Biol. 2017 Apr;18(4):213–213.

Vinson V. This Week in Science: An Interaction that guides cell fate. Science. 2015 Feb 20;347(6224):836.