∆Np63/DGCR8- Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer.

 

IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. 

TAp63 is the master transcriptional regulator of lipid and glucose metabolism 

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

 

DeltaNp63 transcriptionally regulates brachyury, a gene with diverse roles in limb development, tumorigenesis and metastasis

TAp63 prevents premature aging by promoting adult stem cell maintenance

 

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

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  • Faculty of 1000 – rated 6 (William Kaelin, M.D., Professor, Harvard Medical School, Dana Farber Cancer Institute)