Books edited

  Systems Biology of Tumor Dormancy 
  Springer, 2013
  edited by Heiko Enderling, Nava Almog, and Lynn Hlatky
  Publisher Website


Special journal issues edited

"Computational Models in Oncology: from Tumor Initiation to Progression to Treatment",
Special Topic in Frontiers in Molecular and Cellular Oncology, 2013
edited by K.A. Rejniak and H. Enderling
Open Access



Journal articles


50. Integrating mathematical models of T cell tracking into clinical radiotherapy target selection to maximize abscopal responses
R Walker, J Schoenfeld, S Pilon-Thomas, J Poleszczuk, H Enderling. Converg. Sci. Phys. Oncol., accepted, 2017. 

49. Quantitative pretreatment CT volumetry: Association with oncologic outcomes in patients with T4a squamous carcinoma of the larynx
JC Shiao, ASR Mohamed, JA Messer, KA Hutcheson, JM Johnson, H Enderling, M Kamal, BW Warren, B Pham, WH Morrison, ME Zafereo, AC Hessel, SY Lai, MS Kies, R Ferrarotto, AS Garden, DF Schomer, GB Gunn, J Phan, SJ Frank, BM Beadle, RS Weber, JS Lewin, DI Rosenthal, CD Fuller. Head Neck, 2017. [abstract

48. The future of personalised radiotherapy for head and neck cancer
JJ Caudell, JF Torres-Roca, RG Gillies, H Enderling, S Kim, A Rishi, EG Moros, LB Harrison. Lancet Oncol., 18(5): e266-273, 2017. [abstract[Journal]

47. Predicting patient-specific radiotherapy protocols based on mathematical model choice for Proliferation Saturation Index
J Poleszczuk, R Walker, EG Moros, K Latifi, JJ Caudell, H Enderling. Bull. Math. Biol., accepted, 2017.

46. Modeling T cell trafficking to increase the likelihood of radiation-induced abscopal effects
J Poleszczuk, E Moros, M Fishman, R Walker, J Djeu, J Schoenfeld, S Finkelstein, H Enderling. Contemporary Radiation Oncology, accepted, 2017.



45. CT-based volumetric tumor growth velocity: A novel imaging prognostic indicator in oropharyngeal cancer patients receiving radiotherapy
S Perni, AS Mohamed, J Scott, H Enderling, AS Garden, GB Gunn, DI Rosenthal, CD Fuller. Oral Oncol., 63: 16-22, 2016. [abstract]

44. Stratifying prostate cancer patients by relative lymph node involvement: population- and modeling-based study
J Poleszczuk, PA Johnstone, H Enderling. Cancer Med., 5(8): 1850-1855, 2016. [abstract] [Open Access]

43. Agent-based modeling of cancer stem cell driven solid tumor growth
J Poleszczuk, P Macklin, H Enderling. Methods Mol. Biol., 1516: 335-346, 2016. [abstract] [Preprint]

42. Abscopal benefits of localized radiotherapy depend on activated T cell trafficking and distribution within individual metastatic lesions
J Poleszczuk, KA Luddy, SA Prokopiou, M Robertson-Tessi, EG Moros, M Fishman, JY Djeu, SE Finkelstein, H Enderling. Cancer Res., 76(5); 1009-18, 2016. [abstract] [Open Access] [Commentary by Demaria & Formenti]

41. Cancer stem cell plasticity as tumor growth promoter and catalyst of population collapse
J Poleszczuk, H Enderling. Stem Cells Int., 2016:3923527, 2016. [abstract] [Open Access]

40. From concept to clinic: mathematically informed immunotherapy
R Walker, H Enderling. Curr. Probl. Cancer, 40(1): 68-83, 2016. [abstract] [pdf][Preprint]



39. A proliferation saturation index to predict radiation response and personalize radiotherapy fractionation
SA Prokopiou, EG Moros, J Poleszczuk, J Caudell, JF Torres-Roca, K Latifi, R Myerson, LB Harrison, H Enderling. Radiat. Oncol., 10:159, 2015. [abstract] [Open Access]

38. Particle radiation-induced non-targeted effects in bone marrow-derived endothelial progenitor cells
SP Sasi, D Park, S Muralidharan, J Wage, A Kiladjian, J Onufrak, H Enderling, X Yan, D Goukassian. Stem Cells Int., 2015:496512, 2015. [abstract] [Open Access]

37. Mathematical modeling of acupuncture as cancer symptom therapy: First steps
PA Johnstone, H Enderling. J. Acupuncture Meridian Stud., 8(3):113-4, 2015. [abstract] [Open Access]

36. Evolution and phenotypic selection of cancer stem cells
J Poleszczuk, P Hahnfeldt, H Enderling. PLoS Comp. Biol., 11(3):e1004025, 2015. [abstract] [Open Access]

35. Therapeutic implications from sensitivity analysis of tumor angiogenesis models
J Poleszczuk, P Hahnfeldt, H Enderling. PLoS One, 10(3):e0120007, 2015. [abstract] [Open Access]

34. Cancer stem cells: small subpopulation or evolving fraction?
H Enderling. Integr. Biol., 7(1): 14-23, 2015. [abstract] [Open Access]



33. Cardiovascular risks associated with low dose ionizing particle radiation
X Yan, SP Sasi, H Gee, J Lee, Y Yang, R Mehrzad, J Onufrak, J Song, H Enderling, A Agarwal, L Rahimi, J Morgan, PF Wilson, J Carrozza, K Walsh, R Kishore, DA Goukassian. PLoS One, 9(10):e110269, 2014. [abstract] [Open Access]

32. A multi-compartment mathematical model of cancer stem cell driven tumor growth dynamics
SL Weekes, B Barker, S Bober, K Cisneros, J Cline, A Thompson, L Hlatky, P Hahnfeldt, H Enderling. Bull. Math. Biol., 76(7):1762-82, 2014. [abstract] [Open Access]

31. TNF-TNFR2/p75 signaling inhibits early and increases delayed non-targeted effects in bone marrow-derived endothelial progenitor cells
SP Sasi, J Song, D Park, H Enderling, JT McDonald, H Gee, B Garrity, A Shtifman, X Yan, K Walsh, M Natarajan, R Kishore, DA Goukassian. J. Biol. Chem., 289(20):14178-93, 2014. [abstract] [Open Access]

30. Biphasic modulation of cancer stem cell driven solid tumor dynamics in response to reactivated replicative senescence
J Poleszczuk, P Hahnfeldt, H Enderling. Cell Prolif., 47(3):267-76, 2014. [abstract]

29. Therapeutic non-toxic doses of TNF induced remarkable regression in TNFR2-p75 knockdown Lewis lung carcinoma xenografts
SP Sasi, S Bae, J Song, A Perepletchikov, D Schneider, J Carrozza, X Yan, R Kishore,H Enderling, DA Goukassian. PLoS ONE, 9(3): e92373, 2014. [abstract] [Open Access]

28. Mathematical modeling of tumor growth and treatment
H Enderling, MAJ Chaplain. Curr. Pharm. Des., 20(30): 4934-40. [abstract]

27. TNF-α and IL-1α but not MCP-1 and Rantes increase significantly the formation of p-H2AX foci in naive BM-derived TNFR1/p55KO EPCs
SP Sasi, J Song, H Enderling, X Yan, DA Goukassian. J Radiat. Res. , 55: Suppl 1:i122-i123, 2014. [abstract] [Open Access]

26. A high-performance cellular automaton model of tumor growth with dynamcally growing domains
J Poleszczuk, H Enderling. Appl. Math., 5(1): 144-152, 2014. [abstract] [Open Access]


25. Unveiling stem cell kinetics: prime time for integrating experimental and computational models
H Enderling. Front. Oncol., 3:291, 2013. [abstract] [Open Access]

24. Simulating cancer: computational models in oncology
H Enderling, KA Rejniak. Frontiers. Oncol., 3:233, 2013. [abstract] [Open Access]

23. Formalizing an integrative, multidisciplinary cancer therapy discovery workflow
MF McGuire, H Enderling, DI Wallace, JS Batra, M Jordan, S Kumar, C Panetta, E Pasquier. Cancer Res., 73(20):6111-6117, 2013. [abstract] [Open Access]

22. Cancer stem cells: a minor cancer subpopulation that redefines global cancer features
H Enderling, L Hlatky, P Hahnfeldt. Front. Oncol., 3:76, 2013. [abstract] [Open Access]

21. Acute and fractionated irradiation differentially modulate glioma stem cell division kinetics
X Gao, JT McDonald, L Hlatky, H Enderling. Cancer Res., 73(5):1481-1490, 2013. [abstract] [Open Access]

20. Cancer stem cells and tumor dormancy
H Enderling. Adv. Exp. Med. Biol, 734:55-71, 2013. [abstract]
[Systems Biology of Tumor Dormancy Springer, 2013]

19. The tumor growth paradox and immune system-mediated selection for cancer stem cells
T Hillen, H Enderling, P Hahnfeldt. Bul. Math. Biol., 75(1):161-184, 2013. [abstract]


18. Immunoediting: Evidence of the multifaceted role of the immune system in self-metastatic tumor growth
H Enderling, L Hlatky, P Hahnfeldt. Theor. Biol. Med. Model., 9:31, 2012. [abstract] [Open Access]

17. Systems biology of tumor dormancy: linking biology and mathematics on multiple scales to improve cancer therapy
H Enderling, L Hlatky, P Hahnfeldt, N Almog. Cancer Res., 72(9):2172-2175, 2012. [abstract] [Open Access]

16. The promoting role of a tumor-secreted chemorepellent in self-metastatic tumor progression
H Enderling, L Hlatky, P Hahnfeldt. Math. Med. Biol., 29(1):21-29, 2012. [abstract]

15. Breaking the 'harmony' of TNF-α signaling for cancer treatment
SP Sasi, X Yan, H Enderling, D Park, HY Gilbert, C Curry, C Coleman, L Hlatky, G Qin, R Kishore, DA Goukassian. Oncogene, 31(37):4117-27, 2012. [abstract] [Open Access]


14. Non-Stem Cancer Cell Kinetics Modulate Solid Tumor Progression
CI Morton, L Hlatky, P Hahnfeldt, H Enderling. Theor. Biol. Med. Model, 8(1):48, 2011. [abstract] [Open Access]

13. Cancer stem cells in solid tumors: is 'evading apoptosis' a hallmark of cancer?
H Enderling, P Hahnfeldt. Progr. Biophys. Mol. Biol., 106(2), 391-399, 2011. [abstract]

12. Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling
J Tang, H Enderling, S Becker-Weimann, C Pham, A Polyzos, CY Che, SV Costes. Integr. Biol., 3(4):408-421, 2011. [abstract] [Open Access]


11. Quantitative modeling of tumor dynamics and radiotherapy
H Enderling, MAJ Chaplain, P Hahnfeldt. Acta Biotheor., 58(4), 341-353, 2010. [abstract]

10. Tumor morphological evolution: directed migration and gain and loss of the self-metastatic phenotype
H Enderling, L Hlatky, P Hahnfeldt. Biol. Direct, 5:23, 2010. [abstract] [Open Access]


9. Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics
H Enderling, ARA Anderson, MAJ Chaplain, A Beheshti, L Hlatky, P Hahnfeldt.Cancer Res., 69(22), 8814-8821, 2009. [abstract] [Open Access]

8. Reply: Inflammatory breast carcinoma as a model of accelerated self-metastatic expansion by intra-vascular growth
H Enderling, L Hlatky, P Hahnfeldt. Br. J. Cancer, 101(6), 1030, 2009. [Open Access]

7. Migration rules: tumours are conglomerates of self-metastases
H Enderling, L Hlatky, P Hahnfeldt. Br. J. Cancer, 100(12), 1917-1925, 2009. [abstract] [Open Access] [JNCI editorial] [NCI Cancer bulletin]

6. The importance of spatial distribution of stemness and proliferation state in determining tumor radioresponse
H Enderling, D Park, L Hlatky, P Hahnfeldt. Math. Model. Nat. Phenom., 4(3), 117-133, 2009. [abstract] [Open Access]


5. Dependence of invadopodia function on collagen fiber spacing and crosslinking: computational modeling and experimental evidence
H Enderling, NR Alexander, E Clark, KM Branch, L Estrada, C Crooke, J Jourquin, N Lobdell, MH Zaman, SA Guelcher, ARA Anderson, AM Weaver. Biophys. J. 95(5), 2203-2218, 2008. [abstract] [Open Access]


4. A model of breast carcinogenesis and recurrence after radiotherapy
H Enderling, ARA Anderson, MAJ Chaplain. Proc. Appl. Math. Mech. 7(1), 1121701-2, 2007. [abstract]

3. A mathematical model of breast cancer development, local treatment and recurrence
H Enderling, MAJ Chaplain, ARA Anderson, JS Vaidya. J. Theor. Biol. 246(2), 2007. [abstract]


2. Visualisation of the numerical solution of partial differential equation systems in three space dimensions and its importance for mathematical models in biology
H Enderling, ARA Anderson, MAJ Chaplain, GW Rowe. Math. Biosci. Eng. 3(4), 571-582, 2006. [abstract]

1. Mathematical modelling of radiotherapy strategies for early breast cancer
H Enderling, ARA Anderson, MAJ Chaplain, AJ Munro, JS Vaidya. J. Theor. Biol.241(1), 158-171, 2006. [abstract]


Published Abstracts

12. H. pylori Infection Induces Early Expression of CD44 during the Progression of Gastric Cancer.
R Walker, Mejia J, H Enderling, Coppola D. Lab. Invest. 96(Suppl 1): 206A-206A, 2016

11. Proliferation saturation index predicts oropharyngeal squamous cell cancer gross tumor volume reduction to prospectively identify patients for adaptive radiation therapy.
Lewin T, Kim J, Latifi K, J Poleszczuk, Bull J, Byrne H, Torres-Roca J, Moros EG, Gatenby R, Harrison LB, Heukelom J, Mohamed ASR, Rosenthal DI, Fuller CD, Caudell JJ, H Enderling. Int. J. Radiat. Oncol. Biol. Phys. 94(4): 903, 2016

10. CD133 Protein expression as a biomarker for early detection of gastric cancer.
Diffalha SAL, R Walker, H Enderling, Coppola D, Pimiento J, Mejia J. Gastroenterology 150 (4): S874-S875, 2016

9. CD44, CD133 and Lgr5 as biomarkers for early detection of H. pylori-associated gastric cancer.
R Walker, Mejia J, H Enderling, Pimiento JM, Malafa M, Coppola D. The FASEB Journal 30 (1 Suppl): 696.4, 2016.

8. Personalizing the synergy of focal radiation and immunotherapy.
J Poleszczuk, Luddy K, Pilon-Thomas S, Schoenfeld JD, H Enderling. Cancer Res., 76 (14 Supplement): 4016, 2016

7. Cross-disciplinary methods for personalizing screening modalities for early gastric cancer intervention.
R Walker, Majia J, H Enderling, Pimiento JM, Coppola D. Cancer Res. 76 (14 Supplement): 1523, 2016

6. Systems biology approach predicts the diagnostic value of T effector : T regulatory cell ratio in clinical response to combined radiation/immunotherapy of high-risk soft tissue sarcoma.
S Prokopiou, J Poleszczuk, Robertson-Tessi M, Luddy KA, Fishman M, Moros E, Djeu JY, H Enderling. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy: A New Chapter; December 1-4, 2014; Orlando, FL. Philadelphia (PA): AACR; Cancer Immunol Res 3(10 Suppl):Abstract nr A19, 2015.

5. A systems biology approach to predict immunotherapy augmented abscopal effects.
J Poleszczuk, S Prokopiou, Robertson-Tessi M, Luddy KA, Moros E, Fishman M, Djeu JY, H Enderling. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy: A New Chapter; December 1-4, 2014; Orlando, FL. Philadelphia (PA): AACR; Cancer Immunol Res 3(10 Suppl):Abstract nr A18, 2015.

4. TNF-alpha and IL-1 alpha but not MCB-1 and Rantes increase significantly the formation of p-H2AX foci in naive BM-derived TNFR1/P55KO EPCs.
Sasi SP, Song J, Park D, H Enderling, Gee H, Garrity B, Shtifman A, Yan X, Walsh KA, Natarajan M, Kishore R, Goukassian D. J Radiat Res 55(Suppl 1): i122-3, 2014.

3. TNF-TNFR1/p55 or TNFR2/p75 Receptor-Ligand Interactions Inhibit Early and Increase Delayed Radio-Biological Bystander Responses in BM-Derived EPCs.
Muralidharan S, Sasi S, Yan X, H Enderling, Goukassian D. Circ Res 111(4) Supplement 184, 2012.

2. Increased cytokine and chemokine expression in U87MG glioblastoma cells after large clinically relevant single doses of ionizing radiation.
McDonald JT, Lee J, Rietman E, Lamont C, H Enderling, Peluso M, Hlatky L. Cancer Res 72(8), Supplement 1, 2012.

1. Cancer stem cells in solid tumors: Symmetric division, niche size, and invasive tumor morphology.
H Enderling, Hlatky L, Hahnfeldt P. Cancer Res 71(8), Supplement 1, 2011.


Book Chapters

6. Integrating experimental data to calibrate quantitative cancer models
H Enderling. doi:, BioRxiv, 2015.

5. Vectorization techniques for efficient agent-based model simulations of tumor growth
J Poleszczuk, H Enderling. doi:, BioRxiv, 2015.

4. Cancer stem cell kinetics

3. Cell-cell interactions in solid tumors: the role of cancer stem cells
X Gao, JT McDonald, L Hlatky, H Enderling. in: NEW CHALLENGES FOR CANCER SYSTEMS BIOMEDICINE (eds. d'Onofrio, Cerrai, and Gandolfi ), 2012.

2. Mathematical modelling of stem cells related to cancer
MJ Piotrowska, H Enderling, U an der Heiden, MC Mackey. in STEM CELLS AND CANCER (eds. T. Dittmar et al), 2008.

1. Mathematical Modelling of Breast Carcinogenesis, Treatment with Surgery and Radiotherapy, and Local Recurrence
H Enderling, JS Vaidya. in SELECTED TOPICS ON CANCER MODELLING GENESIS - EVOLUTION - IMMUNE COMPETITION - THERAPY (eds. N. Bellomo, M. Chaplain and E. De Angelis), Birkhäuser, 2008.