@EnderlingLab: quantitative models to personalize oncology

Personalized radiotherapy

 

Radiation therapy (RT) is the single most utilized therapeutic agent in oncology, yet advances in radiation oncology have primarily focused on beam properties. One obvious shortcoming of current clinical practice is that RT is planned without regard to any of the tumor-environmental factors that may influence outcome.

We integrate mathematical, computational, biological and clinical sciences to thoroughly investigate tumor growth and response to single or combination therapy. In close collaboration with experimentalists and clinicians, mathematical models that are parameterized with experimental and clinical data can help estimate patient-specific disease dynamics, and predict response to different treatments or treatment protocols.

Tumor-immune ecosystem

 

Tumor-associated antigens, stress proteins, and danger-associated molecular patterns are endogenous immune adjuvants that can both initiate and continually stimulate an immune response against a tumor. In retaliation, tumors can hijack intrinsic immune regulatory programs, thereby facilitating continued growth despite an activated antitumor immune response. Clinically apparent tumors have co-evolved with the patient’s immune system and form a complex Tumor-immune ecosystem.

We combine experimental studies and clinical data to calibrate and rigorously validate mathematical and computational frameworks that simulates the complex adaptive tumor-immune interactions, and how cancer therapies change the tumor-immune ecosystem.

 

Dynamic predictive biomarkers

 

Despite new strategies in “precision medicine” in which the screening or specific therapy is guided by molecular biomarkers, treatment protocols rarely vary between patients. Putative biomarkers are often collected at single time points (such as a genomic profile at biopsy, or cancer stage including tumor size, lymph node involvement, and metastatic load) and are rarely predictive or prognostic.

Our group pioneers the approach to harness patient-specific dynamics as biomarkers for treatment response. With mathematical models describing biomarker dynamics over time, we can make predictions and compare and evaluate clinical responses against the prediction. This identifies actionable triggers for treatment adaptation and quantitative personalized oncology

News

Welcome Rebecca & Stefano

Bekker and Pasetto

This week we welcome Ms. Rebecca Bekker as a rotation Graduate Student to the lab. Rebecca will be working on GRID radiation therapy.

We also welcome Dr. Stefano Pasetto as a Research Associate. Stefano will be working on hurricane models for prostate cancer therapy.

 

EnderlingLab receives R21 to predict patient-specific prostate cancer treatment responses

hipimo

Intermittent androgen deprivation therapy (IADT) is a promising strategy to counteract evolution of resistance in prostate cancer patients. However, successful implementation of IADT requires identification of resistance mechanisms, prediction of responses, and determination of clinically actionable triggers of when to pause and when to resume IADT cycles. 

In this work we propose to develop a mathematical framework to explore the contribution of prostate cancer stem cell dynamics to evolving resistance, and to use these dynamics in computer simulations to reliably forecast the response in subsequent treatment cycles on a per patient basis.

 

On the profession of Mathematical Oncology 

BradyPipeline

Drs. Brady and Enderling publish an opinion article in the Bulletin of Mathematical Biology on the necessary steps for mathematical models to predict novel or optimal cancer theapies. The Brady Pipeline is published open access. 

Brady & Enderling. Bull. Math. Biol., 2019

 

Nuverah Mohsin wins best poster award at RISE Conference

RadiationPaper

Congratulations Nuverah Mohsin on being awarded Best Poster Presentation in Research at the 2019 RISE Conference at NOVA Southeastern University. 

Nuverah, supervised by Dr. Mohammad Zahid, presented her project on a novel approach to simulate tumor response to radiotherapy by varying the tumor carrying capacity in the logistic growth PSI Model. Congratulations Nuverah.